Version 5.4
Mus musculus Protein: Sgcg
Summary
InnateDB Protein IDBP-401083.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sgcg
Protein Name sarcoglycan, gamma (dystrophin-associated glycoprotein)
Synonyms 35kDa; 5430420E18Rik; AI642964; gamma-SG;
Species Mus musculus
Ensembl Protein ENSMUSP00000112576
InnateDB Gene IDBG-171165 (Sgcg)
Protein Structure
UniProt Annotation
Function Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.
Subcellular Localization Cell membrane, sarcolemma {ECO:0000269PubMed:9864373}; Single-pass type II membrane protein {ECO:0000269PubMed:9864373}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:9864373}.
Disease Associations
Tissue Specificity Most strongly expressed in skeletal and heart muscle. Also detected in proliferating myoblasts.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0061024 membrane organization
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005887 integral component of plasma membrane
GO:0016011 dystroglycan complex
GO:0016012 sarcoglycan complex
GO:0016021 integral component of membrane
GO:0042383 sarcolemma
Protein Structure and Domains
PDB ID MGI:1346524
InterPro IPR006875 Sarcoglycan complex subunit protein
PFAM PF04790
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P82348
PhosphoSite PhosphoSite-P82348
TrEMBL Q9EQ83
UniProt Splice Variant
Entrez Gene 24053
UniGene Mm.72173
RefSeq
MGI ID
MGI Symbol Sgcg
OMIM
CCDS CCDS27181
HPRD
IMGT
EMBL AB024922 AF282901 AK132610 BC138960 BC138961 CH466535
GenPept AAG16770 AAI38961 AAI38962 BAA83493 BAE21260 EDL36106

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca