Version 5.4
Mus musculus Gene: Sgcg
Summary
InnateDB Gene IDBG-171165.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sgcg
Gene Name sarcoglycan, gamma (dystrophin-associated glycoprotein)
Synonyms 35kDa; 5430420E18Rik; AI642964; gamma-SG
Species Mus musculus
Ensembl Gene ENSMUSG00000035296
Encoded Proteins
IDBP-171167
sarcoglycan, gamma (dystrophin-associated glycoprotein)
IDBP-401083
sarcoglycan, gamma (dystrophin-associated glycoprotein)
IDBP-538213
sarcoglycan, gamma (dystrophin-associated glycoprotein)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000102683:
This gene encodes gamma-sarcoglycan, one of several sarcolemmal transmembrane glycoproteins that interact with dystrophin. The dystrophin-glycoprotein complex (DGC) spans the sarcolemma and is comprised of dystrophin, syntrophin, alpha- and beta-dystroglycans and sarcoglycans. The DGC provides a structural link between the subsarcolemmal cytoskeleton and the extracellular matrix of muscle cells. Defects in the encoded protein can lead to early onset autosomal recessive muscular dystrophy, in particular limb-girdle muscular dystrophy, type 2C (LGMD2C). [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:61221059-61258490
Strand Reverse strand
Band D1
Transcripts
ENSMUST00000077954 ENSMUSP00000077106
ENSMUST00000121148 ENSMUSP00000112576
ENSMUST00000129886 ENSMUSP00000117191
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0061024 membrane organization
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005887 integral component of plasma membrane
GO:0016011 dystroglycan complex
GO:0016012 sarcoglycan complex
GO:0016021 integral component of membrane
GO:0042383 sarcolemma
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000102683
View Gene Order
ENSBTAG00000001865
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
mmu05410
Hypertrophic cardiomyopathy (HCM) pathway
mmu05414
Dilated cardiomyopathy pathway
mmu05416
Viral myocarditis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
hsa05410
Hypertrophic cardiomyopathy (HCM) pathway
hsa05414
Dilated cardiomyopathy pathway
hsa05416
Viral myocarditis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.72173
RefSeq NM_011892 XM_006519012
OMIM
CCDS CCDS27181
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca