InnateDB Protein
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IDBP-401113.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Dixdc1
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Protein Name
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DIX domain containing 1
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000113934
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InnateDB Gene
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IDBG-163830 (Dixdc1)
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Protein Structure
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Function |
Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2. {ECO:0000269PubMed:15262978, ECO:0000269PubMed:15857680}.
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Subcellular Localization |
Cell junction, focal adhesion {ECO:0000250}. Cytoplasm {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Note=Colocalizes with gamma-tubulin at the centrosome, both during interphase and mitosis. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Abundantly expressed in brain and testis and to a lower extent in lung, kidney, colon, ovary and urinary bladder. Expressed in brain, liver, testis and spleen (at protein level). Expressed throughout the brain with strong expression in main and accessory olfactory bulbs, cerebral cortex, piriform cortex, hippocampus, habenular nucleus, dorsal thalamus, superior and inferior colliculi and cerebellum. {ECO:0000269PubMed:15857680}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
6 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2679721
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q80Y83
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PhosphoSite |
PhosphoSite-Q80Y83
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
330938
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UniGene |
Mm.82598
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RefSeq |
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MGI ID |
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MGI Symbol |
Dixdc1
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AK082960
AK129432
AK142668
AK164424
AY549883
AY549884
AY549885
AY549886
AY549887
BC024834
BC048182
BC063085
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GenPept |
AAH24834
AAH48182
AAH63085
AAT41660
AAT41661
AAT41662
AAT41663
AAT41664
BAC38711
BAC98242
BAE25153
BAE37782
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