InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ift88

Summary

InnateDB Protein

IDBP-401123.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ift88

Protein Name

intraflagellar transport 88 homolog (Chlamydomonas)

Synonyms

AW552028; flexo; fxo; orpk; polaris; Tg737; Tg737Rpw; TgN737Rpw; Ttc10;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000113768

InnateDB Gene

IDBG-168502 (Ift88)

Protein Structure

UniProt Annotation

Function

Involved in primary cilium biogenesis. Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment. {ECO:0000269PubMed:11062270, ECO:0000269PubMed:21289087}.

Subcellular Localization

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, cilium basal body.

Disease Associations

Note=Defects in Ift88 are the cause of recessive bilateral polycystic kidney disease (PKD) with collecting duct and tubule ectasia, and a liver lesion involving biliary dysplasia and/or portal fibrosis.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0001654	eye development
GO:0001822	kidney development
GO:0001889	liver development
GO:0003382	epithelial cell morphogenesis
GO:0007219	Notch signaling pathway
GO:0007224	smoothened signaling pathway
GO:0007288	sperm axoneme assembly
GO:0007290	spermatid nucleus elongation
GO:0007368	determination of left/right symmetry
GO:0007399	nervous system development
GO:0007420	brain development
GO:0007507	heart development
GO:0008104	protein localization
GO:0008544	epidermis development
GO:0008589	regulation of smoothened signaling pathway
GO:0009887	organ morphogenesis
GO:0009952	anterior/posterior pattern specification
GO:0009953	dorsal/ventral pattern formation
GO:0021513	spinal cord dorsal/ventral patterning
GO:0021537	telencephalon development
GO:0030324	lung development
GO:0031016	pancreas development
GO:0031122	cytoplasmic microtubule organization
GO:0034405	response to fluid shear stress
GO:0036334	epidermal stem cell homeostasis
GO:0042384	cilium assembly
GO:0042487	regulation of odontogenesis of dentin-containing tooth
GO:0042733	embryonic digit morphogenesis
GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway
GO:0045598	regulation of fat cell differentiation
GO:0048853	forebrain morphogenesis
GO:0050680	negative regulation of epithelial cell proliferation
GO:0055007	cardiac muscle cell differentiation
GO:0060021	palate development
GO:0060122	inner ear receptor stereocilium organization
GO:0060173	limb development
GO:0060271	cilium morphogenesis
GO:0060411	cardiac septum morphogenesis
GO:0060426	lung vasculature development
GO:0060914	heart formation
GO:0070613	regulation of protein processing
GO:0090102	cochlea development
GO:1902017	regulation of cilium assembly
GO:2000785	regulation of autophagic vacuole assembly

Cellular Component

GO:0002080	acrosomal membrane
GO:0005813	centrosome
GO:0005814	centriole
GO:0005929	cilium
GO:0005930	axoneme
GO:0030992	intraciliary transport particle B
GO:0031512	motile primary cilium
GO:0032391	photoreceptor connecting cilium
GO:0036064	ciliary basal body
GO:0045177	apical part of cell
GO:0060091	kinocilium
GO:0072372	primary cilium
GO:0097541	axonemal basal plate
GO:0097542	ciliary tip
GO:0097546	ciliary base