Version 5.4
Mus musculus Gene: Ift88
Summary
InnateDB Gene IDBG-168502.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ift88
Gene Name intraflagellar transport 88
Synonyms AW552028; flexo; fxo; orpk; polaris; Tg737; Tg737Rpw; TgN737Rpw; Ttc10
Species Mus musculus
Ensembl Gene ENSMUSG00000040040
Encoded Proteins
IDBP-401123
intraflagellar transport 88 homolog (Chlamydomonas)
IDBP-537388
intraflagellar transport 88 homolog (Chlamydomonas)
IDBP-620325
intraflagellar transport 88 homolog (Chlamydomonas)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000032742:
This gene encodes a member of the tetratrico peptide repeat (TPR) family. Mutations of a similar gene in mouse can cause polycystic kidney disease. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:57424062-57517936
Strand Forward strand
Band C3
Transcripts
ENSMUST00000122063 ENSMUSP00000113768
ENSMUST00000150296 ENSMUSP00000120286
ENSMUST00000154492
ENSMUST00000139943
ENSMUST00000171682 ENSMUSP00000130475
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001654 eye development
GO:0001822 kidney development
GO:0001889 liver development
GO:0003382 epithelial cell morphogenesis
GO:0007219 Notch signaling pathway
GO:0007224 smoothened signaling pathway
GO:0007288 sperm axoneme assembly
GO:0007290 spermatid nucleus elongation
GO:0007368 determination of left/right symmetry
GO:0007399 nervous system development
GO:0007420 brain development
GO:0007507 heart development
GO:0008104 protein localization
GO:0008544 epidermis development
GO:0008589 regulation of smoothened signaling pathway
GO:0009887 organ morphogenesis
GO:0009952 anterior/posterior pattern specification
GO:0009953 dorsal/ventral pattern formation
GO:0021513 spinal cord dorsal/ventral patterning
GO:0021537 telencephalon development
GO:0030324 lung development
GO:0031016 pancreas development
GO:0031122 cytoplasmic microtubule organization
GO:0034405 response to fluid shear stress
GO:0036334 epidermal stem cell homeostasis
GO:0042384 cilium assembly
GO:0042487 regulation of odontogenesis of dentin-containing tooth
GO:0042733 embryonic digit morphogenesis
GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway
GO:0045598 regulation of fat cell differentiation
GO:0048853 forebrain morphogenesis
GO:0050680 negative regulation of epithelial cell proliferation
GO:0055007 cardiac muscle cell differentiation
GO:0060021 palate development
GO:0060122 inner ear receptor stereocilium organization
GO:0060173 limb development
GO:0060271 cilium morphogenesis
GO:0060411 cardiac septum morphogenesis
GO:0060426 lung vasculature development
GO:0060914 heart formation
GO:0070613 regulation of protein processing
GO:0090102 cochlea development
GO:1902017 regulation of cilium assembly
GO:2000785 regulation of autophagic vacuole assembly
Cellular Component
GO:0002080 acrosomal membrane
GO:0005813 centrosome
GO:0005814 centriole
GO:0005929 cilium
GO:0005930 axoneme
GO:0030992 intraciliary transport particle B
GO:0031512 motile primary cilium
GO:0032391 photoreceptor connecting cilium
GO:0036064 ciliary basal body
GO:0045177 apical part of cell
GO:0060091 kinocilium
GO:0072372 primary cilium
GO:0097541 axonemal basal plate
GO:0097542 ciliary tip
GO:0097546 ciliary base
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000032742
View Gene Order
ENSBTAG00000014286
Not yet available
Pathways
NETPATH
REACTOME
REACT_269412
Hedgehog 'off' state pathway
REACT_250064
Signaling by Hedgehog pathway
REACT_188257
Signal Transduction pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_228134
Signaling by Hedgehog pathway
REACT_111102
Signal Transduction pathway
REACT_267634
Hedgehog 'off' state pathway
KEGG
INOH
PID NCI
hedgehog_glipathway
Hedgehog signaling events mediated by Gli proteins
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.4653
RefSeq NM_009376 XM_006518811 XM_006518812
OMIM
CCDS CCDS36937
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca