InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fkbp8

Summary

InnateDB Protein

IDBP-401131.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fkbp8

Protein Name

FK506 binding protein 8

Synonyms

38kDa; FKBP-38; FKBP-8; Fkbp38;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000112527

InnateDB Gene

IDBG-163357 (Fkbp8)

Protein Structure

UniProt Annotation

Function

Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis (By similarity). Required for normal embryonic development. {ECO:0000250}.

Subcellular Localization

Mitochondrion membrane {ECO:0000269PubMed:15105374}; Single-pass membrane protein {ECO:0000269PubMed:15105374}; Cytoplasmic side {ECO:0000269PubMed:15105374}.

Disease Associations

Tissue Specificity

Detected throughout the embryonic body, in caudal neural tube, limbs and head. Detected in adult retina, brain, heart, kidney, liver, pancreas, lung, testis and urinary bladder (at protein level). Detected in adult brain, kidney, liver, testis and trigeminal nerve, and in embryo. Detected at lower levels in lung, spleen, heart and ovary. Widely expressed in forebrain. Detected in the Purkinje cell layer in the cerebellum and in hippocampus neurons. {ECO:0000269PubMed:10197430, ECO:0000269PubMed:14667822, ECO:0000269PubMed:15105374}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 71 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	71 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003755	peptidyl-prolyl cis-trans isomerase activity
GO:0005515	protein binding
GO:0005528	FK506 binding

Biological Process

GO:0000413	protein peptidyl-prolyl isomerization
GO:0001708	cell fate specification
GO:0006457	protein folding
GO:0006915	apoptotic process
GO:0007224	smoothened signaling pathway
GO:0009953	dorsal/ventral pattern formation
GO:0010468	regulation of gene expression
GO:0018208	peptidyl-proline modification
GO:0021904	dorsal/ventral neural tube patterning
GO:0021915	neural tube development
GO:0030510	regulation of BMP signaling pathway
GO:0030513	positive regulation of BMP signaling pathway
GO:0035264	multicellular organism growth
GO:0043010	camera-type eye development
GO:0043066	negative regulation of apoptotic process

Cellular Component

GO:0005739	mitochondrion
GO:0005740	mitochondrial envelope
GO:0030176	integral component of endoplasmic reticulum membrane
GO:0031966	mitochondrial membrane

Protein Structure and Domains

PDB ID

MGI:1341070

InterPro

IPR001179 Peptidyl-prolyl cis-trans isomerase, FKBP-type, domain
IPR001440 Tetratricopeptide TPR1
IPR013026 Tetratricopeptide repeat-containing domain
IPR013105 Tetratricopeptide TPR2
IPR019734 Tetratricopeptide repeat

PFAM

PF00254
PF00515
PF07719
PF13174
PF13176
PF13181

PRINTS

PIRSF

SMART

SM00028

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O35465