Version 5.4
Mus musculus Gene: Fkbp8
Summary
InnateDB Gene IDBG-163357.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fkbp8
Gene Name FK506 binding protein 8
Synonyms 38kDa; FKBP-38; FKBP-8; Fkbp38
Species Mus musculus
Ensembl Gene ENSMUSG00000019428
Encoded Proteins
IDBP-163359
FK506 binding protein 8
IDBP-401131
FK506 binding protein 8
IDBP-401130
FK506 binding protein 8
IDBP-401129
FK506 binding protein 8
IDBP-532654
FK506 binding protein 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105701:
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Unlike the other members of the family, this encoded protein does not seem to have PPIase/rotamase activity. It may have a role in neurons associated with memory function. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:70527724-70535328
Strand Forward strand
Band B3.3
Transcripts
ENSMUST00000075491 ENSMUSP00000074935
ENSMUST00000119353 ENSMUSP00000112527
ENSMUST00000119698 ENSMUSP00000114069
ENSMUST00000119425 ENSMUSP00000113528
ENSMUST00000144766
ENSMUST00000128513
ENSMUST00000125741
ENSMUST00000123052
ENSMUST00000134299
ENSMUST00000126613
ENSMUST00000134893 ENSMUSP00000118843
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 71 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 71 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003755 peptidyl-prolyl cis-trans isomerase activity
GO:0005515 protein binding
GO:0005528 FK506 binding
GO:0042802 identical protein binding
Biological Process
GO:0000413 protein peptidyl-prolyl isomerization
GO:0001708 cell fate specification
GO:0006457 protein folding
GO:0006915 apoptotic process
GO:0007224 smoothened signaling pathway
GO:0009953 dorsal/ventral pattern formation
GO:0010468 regulation of gene expression
GO:0018208 peptidyl-proline modification
GO:0021904 dorsal/ventral neural tube patterning
GO:0021915 neural tube development
GO:0030510 regulation of BMP signaling pathway
GO:0030513 positive regulation of BMP signaling pathway
GO:0035264 multicellular organism growth
GO:0043010 camera-type eye development
GO:0043066 negative regulation of apoptotic process
Cellular Component
GO:0005739 mitochondrion
GO:0005740 mitochondrial envelope
GO:0016020 membrane
GO:0030176 integral component of endoplasmic reticulum membrane
GO:0031966 mitochondrial membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000105701
View Gene Order
ENSBTAG00000016264
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
INOH website
Insulin receptor signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
INOH website
Insulin receptor signaling pathway
PID NCI
nfat_3pathway
Role of Calcineurin-dependent NFAT signaling in lymphocytes
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.141864 Mm.453102
RefSeq NM_001111066 NM_001199631 NM_010223 XM_006509554 XM_006509555
OMIM
CCDS CCDS52575 CCDS52576
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca