InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Brd4

Summary

InnateDB Protein

IDBP-401202.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Brd4

Protein Name

bromodomain containing 4

Synonyms

Brd5; HUNK1; MCAP; WI-11513;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000113197

InnateDB Gene

IDBG-165269 (Brd4)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	9 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	40 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002039	p53 binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0070577	lysine-acetylated histone binding

Biological Process

GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0001833	inner cell mass cell proliferation
GO:0006338	chromatin remodeling
GO:0006351	transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0007059	chromosome segregation
GO:0010971	positive regulation of G2/M transition of mitotic cell cycle
GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043388	positive regulation of DNA binding
GO:0043983	histone H4-K12 acetylation
GO:0044154	histone H3-K14 acetylation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050727	regulation of inflammatory response
GO:1901407	regulation of phosphorylation of RNA polymerase II C-terminal domain
GO:2000002	negative regulation of DNA damage checkpoint

Cellular Component

GO:0000790	nuclear chromatin
GO:0000794	condensed nuclear chromosome
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0008024	positive transcription elongation factor complex b