InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Brd4

Summary

InnateDB Gene

IDBG-165269.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Brd4

Gene Name

bromodomain containing 4

Synonyms

Brd5; HUNK1; MCAP; WI-11513

Species

Mus musculus

Ensembl Gene

ENSMUSG00000024002

Encoded Proteins

IDBP-165271

bromodomain containing 4

IDBP-251680

bromodomain containing 4

IDBP-401203

bromodomain containing 4

IDBP-401202

bromodomain containing 4

IDBP-401201

bromodomain containing 4

IDBP-540016

bromodomain containing 4

IDBP-533359

bromodomain containing 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene was temporarily named bromodomain-containing 5 (Brd5) and was renamed bromodomain-containing 4 (Brd4). [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:32196274-32284722

Strand

Reverse strand

Band

Transcripts

ENSMUST00000003726	ENSMUSP00000003726
ENSMUST00000114475	ENSMUSP00000110119
ENSMUST00000121285	ENSMUSP00000113070
ENSMUST00000119123	ENSMUSP00000113197
ENSMUST00000120276	ENSMUSP00000112474
ENSMUST00000127893	ENSMUSP00000115163
ENSMUST00000125899	ENSMUSP00000115277

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	9 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	40 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002039	p53 binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0070577	lysine-acetylated histone binding

Biological Process

GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0001833	inner cell mass cell proliferation
GO:0006338	chromatin remodeling
GO:0006351	transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0007059	chromosome segregation
GO:0010971	positive regulation of G2/M transition of mitotic cell cycle
GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043388	positive regulation of DNA binding
GO:0043983	histone H4-K12 acetylation
GO:0044154	histone H3-K14 acetylation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050727	regulation of inflammatory response
GO:1901407	regulation of phosphorylation of RNA polymerase II C-terminal domain
GO:2000002	negative regulation of DNA damage checkpoint

Cellular Component

GO:0000790	nuclear chromatin
GO:0000794	condensed nuclear chromosome
GO:0005634	nucleus
GO:0005694	chromosome
GO:0005737	cytoplasm
GO:0008024	positive transcription elongation factor complex b

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000141867

View Gene Order

ENSBTAG00000002495

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_24

TSLP pathway

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

Q9ESU6

TrEMBL

B0V2V6 B2RSE4 Q3U3Z2

UniProt Splice Variant

Entrez Gene

57261

UniGene

Mm.253518 Mm.395253

RefSeq

NM_198094 XM_006524696 NM_001286630 NM_020508 XM_006524683 XM_006524684 XM_006524685 XM_006524686 XM_006524687 XM_006524688 XM_006524689 XM_006524692 XM_006524694 XM_006524695

OMIM

CCDS

CCDS37554 CCDS50057 CCDS70784

HPRD

IMGT

MGI ID

MGI:1888520

MGI Symbol

Brd4

EMBL

AF273217 AF461395 AF461396 AK154514 BC138834 BC138835 CH466640 CT033751 CT033755

GenPept

AAG02191 AAI38835 AAI38836 AAL67833 AAL67834 BAE32643 EDL40326 EDL40327 EDL40329

RNA Seq Atlas

57261