Version 5.4
Mus musculus Protein: Pld3
Summary
InnateDB Protein IDBP-401217.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pld3
Protein Name phospholipase D family, member 3
Synonyms Sam-9;
Species Mus musculus
Ensembl Protein ENSMUSP00000113820
InnateDB Gene IDBG-161294 (Pld3)
Protein Structure
UniProt Annotation
Function Probably involved in APP processing. {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed at higher level in brain than in non-nervous tissue. Probably highly expressed in neurons. Expressed in mature neurons of the forebrain and appears to be turned on at late stages of neurogenesis. Expressed during late neuronal development in the forebrain. {ECO:0000269PubMed:9813063}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004630 phospholipase D activity
GO:0005515 protein binding
GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity
Biological Process
GO:0008152 metabolic process
GO:0016042 lipid catabolic process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1333782
InterPro IPR001736 Phospholipase D/Transphosphatidylase
PFAM PF00614
PRINTS
PIRSF
SMART SM00155
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O35405
PhosphoSite PhosphoSite-O35405
TrEMBL Q9CW68
UniProt Splice Variant
Entrez Gene 18807
UniGene Mm.6483
RefSeq NP_035246
MGI ID
MGI Symbol Pld3
OMIM
CCDS CCDS21025
HPRD
IMGT
EMBL AC158304 AF026124 AK003045 AK153508 BC076586
GenPept AAC73069 AAH76586 BAB22530 BAE32053

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca