Version 5.4
Mus musculus Gene: Pld3
Summary
InnateDB Gene IDBG-161294.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pld3
Gene Name phospholipase D family, member 3
Synonyms Sam-9
Species Mus musculus
Ensembl Gene ENSMUSG00000003363
Encoded Proteins
IDBP-401217
phospholipase D family, member 3
IDBP-401216
phospholipase D family, member 3
IDBP-532196
phospholipase D family, member 3
IDBP-535249
phospholipase D family, member 3
IDBP-532148
phospholipase D family, member 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105223:
This gene encodes a member of the phospholipase D (PLD) family of enzymes that catalyze the hydrolysis of membrane phospholipids. The encoded protein is a single-pass type II membrane protein and contains two PLD phosphodiesterase domains. This protein influences processing of amyloid-beta precursor protein. Mutations in this gene are associated with Alzheimer disease risk. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Apr 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:27532000-27553218
Strand Reverse strand
Band A3
Transcripts
ENSMUST00000117095 ENSMUSP00000113820
ENSMUST00000117611 ENSMUSP00000112942
ENSMUST00000155287
ENSMUST00000142981
ENSMUST00000131106 ENSMUSP00000119228
ENSMUST00000127240 ENSMUSP00000115891
ENSMUST00000150964 ENSMUSP00000122897
ENSMUST00000143903
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004630 phospholipase D activity
GO:0005515 protein binding
GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity
Biological Process
GO:0008152 metabolic process
GO:0016042 lipid catabolic process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000105223
View Gene Order
ENSBTAG00000019150
Not yet available
Pathways
NETPATH
REACTOME
REACT_199032
Synthesis of PG pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_188641
Glycerophospholipid biosynthesis pathway
REACT_188643
Phospholipid metabolism pathway
KEGG
mmu00564
Glycerophospholipid metabolism pathway
mmu00565
Ether lipid metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_160158
Role of phospholipids in phagocytosis pathway
REACT_121280
Synthesis of PG pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_6802
Innate Immune System pathway
REACT_121401
Glycerophospholipid biosynthesis pathway
REACT_6900
Immune System pathway
REACT_120870
Phospholipid metabolism pathway
REACT_160123
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_111217
Metabolism pathway
REACT_202421
Glycerophospholipid biosynthesis pathway
REACT_206590
Synthesis of PG pathway
REACT_219933
Metabolism of lipids and lipoproteins pathway
REACT_219139
Metabolism pathway
REACT_218329
Phospholipid metabolism pathway
KEGG
hsa00564
Glycerophospholipid metabolism pathway
hsa00565
Ether lipid metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.6483
RefSeq NM_011116 XM_006539642
OMIM
CCDS CCDS21025
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca