Version 5.4
Mus musculus Protein: Ltbp4
Summary
InnateDB Protein IDBP-401228.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ltbp4
Protein Name latent transforming growth factor beta binding protein 4
Synonyms 2310046A13Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000113674
InnateDB Gene IDBG-160426 (Ltbp4)
Protein Structure
UniProt Annotation
Function May be involved in the assembly, secretion and targeting of TGFB1 to sites at which it is stored and/or activated. May play critical roles in controlling and directing the activity of TGFB1. May have a structural role in the extra cellular matrix (ECM) (By similarity). {ECO:0000250}.
Subcellular Localization Secreted, extracellular space, extracellular matrix.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0050431 transforming growth factor beta binding
Biological Process
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0030162 regulation of proteolysis
GO:0046879 hormone secretion
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID MGI:1321395
InterPro IPR000742 Epidermal growth factor-like domain
IPR001881 EGF-like calcium-binding domain
IPR017878 TB domain
PFAM PF00008
PF07645
PF00683
PRINTS
PIRSF
SMART SM00181
SM00179
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8K4G1
PhosphoSite PhosphoSite-Q8K4G1
TrEMBL
UniProt Splice Variant
Entrez Gene 108075
UniGene Mm.272251
RefSeq NP_001107021
MGI ID
MGI Symbol Ltbp4
OMIM
CCDS CCDS52158
HPRD
IMGT
EMBL AC157561 AF410798 AF410799 BC059016
GenPept AAH59016 AAN04661 AAN04662

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca