InnateDB Protein
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IDBP-401249.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Tbata
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Protein Name
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thymus, brain and testes associated
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Synonyms
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1700021K02Rik; AI428928; Spatial; Titest;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000113902
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InnateDB Gene
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IDBG-155198 (Tbata)
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Protein Structure
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Function |
Isoform 1 and isoform 2 may play a role in spermatid differentiation. Isoform 1 and isoform 2 regulate thymus function by modulating stromal cell proliferation via interference with the NEDD8 pathway. {ECO:0000269PubMed:17196196, ECO:0000269PubMed:20937703}.
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Subcellular Localization |
Isoform 1: Cytoplasm, cytosol {ECO:0000269PubMed:17196196}. Note=Located throughout the cytosol of early round spermatids. By the end stages of round spermatid development, concentrated at the side of the cell near the nascent flagellum and in the manchette. In mature sperm, located in the principle piece of the tail. {ECO:0000269PubMed:17196196}.Isoform 2: Cytoplasm, cytosol {ECO:0000269PubMed:17196196}. Note=Located throughout the cytosol of early round spermatids. By the end stages of round spermatid development, concentrated at the side of the cell near the nascent flagellum and in the manchette. In mature sperm, located in the principle piece of the tail. {ECO:0000269PubMed:17196196}.Isoform 6: Nucleus {ECO:0000269PubMed:11196687}.Isoform 7: Nucleus {ECO:0000269PubMed:11196687}.
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Disease Associations |
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Tissue Specificity |
Expressed in the subcapsular region of the thymus and lymph node (at protein level). Highly expressed in thymic cortical stromal cells and testis. Lower levels found in brain cortex, hippocampus, kidney, cerebellum, skeletal muscle, epididymis and ovary. No expression detected in other lymphoid organs including bone marrow and spleen. Isoform 1 and isoform 2 are expressed predominantly in testis. Isoform 3, isoform 4 and isoform 5 are expressed predominantly in thymus although isoform 3 is also expressed in testis. In the CNS, highly expressed in restricted areas, the cerebellum and hippocampus. {ECO:0000269PubMed:12711538}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1923820
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q7TSD4
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PhosphoSite |
PhosphoSite-Q7TSD4
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
65971
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UniGene |
Mm.30227
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RefSeq |
NP_001017419
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MGI ID |
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MGI Symbol |
Tbata
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OMIM |
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CCDS |
CCDS48572
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HPRD |
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IMGT |
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EMBL |
AF257502
AF257503
AF521591
AF521592
AK038284
AY243457
AY243458
AY243459
EU622858
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GenPept |
AAG37103
AAG37104
AAP41210
AAP41211
AAP41212
AAP50907
AAP50908
ACD01420
BAC29958
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