InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sgpl1

Summary

InnateDB Protein

IDBP-401250.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sgpl1

Protein Name

sphingosine phosphate lyase 1

Synonyms

AI428538; D10Xrf456; S1PL; Spl;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000112975

InnateDB Gene

IDBG-155094 (Sgpl1)

Protein Structure

UniProt Annotation

Function

Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis. {ECO:0000269PubMed:9464245}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Highest levels are found in liver, followed by kidney, lung, heart and brain. {ECO:0000269PubMed:9464245}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	8 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008117	sphinganine-1-phosphate aldolase activity
GO:0016831	carboxy-lyase activity
GO:0030170	pyridoxal phosphate binding

Biological Process

GO:0001553	luteinization
GO:0001570	vasculogenesis
GO:0001822	kidney development
GO:0006631	fatty acid metabolic process
GO:0006672	ceramide metabolic process
GO:0006807	nitrogen compound metabolic process
GO:0007283	spermatogenesis
GO:0008152	metabolic process
GO:0008209	androgen metabolic process
GO:0008210	estrogen metabolic process
GO:0008585	female gonad development
GO:0009058	biosynthetic process
GO:0009791	post-embryonic development
GO:0010761	fibroblast migration
GO:0019752	carboxylic acid metabolic process
GO:0030097	hemopoiesis
GO:0033327	Leydig cell differentiation
GO:0040014	regulation of multicellular organism growth
GO:0048008	platelet-derived growth factor receptor signaling pathway
GO:0048705	skeletal system morphogenesis
GO:0060021	palate development
GO:0060325	face morphogenesis
GO:0097194	execution phase of apoptosis

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1261415

InterPro

IPR000192 Aminotransferase, class V/Cysteine desulfurase
IPR002129 Pyridoxal phosphate-dependent decarboxylase
IPR004839 Aminotransferase, class I/classII
IPR015424 Pyridoxal phosphate-dependent transferase

PFAM

PF00266
PF00282
PF00155

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8R0X7

PhosphoSite