Version 5.4
Mus musculus Protein: Syk
Summary
InnateDB Protein IDBP-401285.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Syk
Protein Name spleen tyrosine kinase
Synonyms Sykb;
Species Mus musculus
Ensembl Protein ENSMUSP00000112914
InnateDB Gene IDBG-152695 (Syk)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 50 experimentally validated interaction(s) in this database.
They are also associated with 102 interaction(s) predicted by orthology.
Experimentally validated
Total 50 [view]
Protein-Protein 49 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 102 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0004716 receptor signaling protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0000187 activation of MAPK activity
GO:0001820 serotonin secretion
GO:0006468 protein phosphorylation
GO:0007166 cell surface receptor signaling pathway
GO:0007167 enzyme linked receptor protein signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007257 activation of JUN kinase activity
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019370 leukotriene biosynthetic process
GO:0035556 intracellular signal transduction
GO:0043306 positive regulation of mast cell degranulation
GO:0043366 beta selection
GO:0045087 innate immune response (InnateDB)
GO:0045401 positive regulation of interleukin-3 biosynthetic process
GO:0045425 positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process
GO:0045579 positive regulation of B cell differentiation
GO:0045588 positive regulation of gamma-delta T cell differentiation
GO:0046638 positive regulation of alpha-beta T cell differentiation
GO:0046641 positive regulation of alpha-beta T cell proliferation
GO:0046777 protein autophosphorylation
GO:0050715 positive regulation of cytokine secretion
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050850 positive regulation of calcium-mediated signaling
GO:0050853 B cell receptor signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0019815 B cell receptor complex
GO:0043234 protein complex
Protein Structure and Domains
PDB ID MGI:99515
InterPro IPR000719 Protein kinase domain
IPR000980 SH2 domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR012234 Tyrosine-protein kinase, non-receptor SYK/ZAP-70
IPR020635 Tyrosine-protein kinase, catalytic domain
PFAM PF00069
PF00017
PF14633
PF07714
PRINTS PR00401
PR00109
PIRSF PIRSF000604
SMART SM00252
SM00220
SM00219
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL E9PWE9
UniProt Splice Variant
Entrez Gene 20963
UniGene Mm.375031
RefSeq
MGI ID
MGI Symbol Syk
OMIM
CCDS
HPRD
IMGT
EMBL AC159192 AC160765
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca