InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rapgef2

Summary

InnateDB Protein

IDBP-401303.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rapgef2

Protein Name

Rap guanine nucleotide exchange factor (GEF) 2

Synonyms

5830453M24Rik; CNRasGEF; mKIAA0313; nRapGEP; Pdzgef1; RA-GEF-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000113778

InnateDB Gene

IDBG-152904 (Rapgef2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005088	Ras guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0017034	Rap guanyl-nucleotide exchange factor activity
GO:0019901	protein kinase binding
GO:0030165	PDZ domain binding
GO:0030552	cAMP binding
GO:0031697	beta-1 adrenergic receptor binding
GO:0046582	Rap GTPase activator activity
GO:0050699	WW domain binding

Biological Process

GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007218	neuropeptide signaling pathway
GO:0007264	small GTPase mediated signal transduction
GO:0008285	negative regulation of cell proliferation
GO:0010976	positive regulation of neuron projection development
GO:0031175	neuron projection development
GO:0031547	brain-derived neurotrophic factor receptor signaling pathway
GO:0032320	positive regulation of Ras GTPase activity
GO:0032486	Rap protein signal transduction
GO:0032854	positive regulation of Rap GTPase activity
GO:0038180	nerve growth factor signaling pathway
GO:0043950	positive regulation of cAMP-mediated signaling
GO:0045860	positive regulation of protein kinase activity
GO:0048167	regulation of synaptic plasticity
GO:0050774	negative regulation of dendrite morphogenesis
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0061028	establishment of endothelial barrier
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0071320	cellular response to cAMP
GO:0071321	cellular response to cGMP
GO:0071880	adenylate cyclase-activating adrenergic receptor signaling pathway
GO:1901888	regulation of cell junction assembly
GO:1990090	cellular response to nerve growth factor stimulus
GO:2000481	positive regulation of cAMP-dependent protein kinase activity
GO:2000670	positive regulation of dendritic cell apoptotic process

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005770	late endosome
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0043234	protein complex
GO:0045202	synapse
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:2659071

InterPro

IPR000159 Ras-association
IPR000595 Cyclic nucleotide-binding domain
IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
IPR001478 PDZ domain
IPR001895 Guanine-nucleotide dissociation stimulator CDC25
IPR018490 Cyclic nucleotide-binding-like
IPR023578 Ras guanine nucleotide exchange factor, domain
IPR029071 Ubiquitin-related domain

PFAM

PF00788
PF00027
PF00618
PF00595
PF13180
PF00617

PRINTS

PIRSF

SMART

SM00314
SM00100
SM00229
SM00228
SM00147

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite