InnateDB Protein
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IDBP-401383.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Mtus1
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Protein Name
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mitochondrial tumor suppressor 1
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Synonyms
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AI481402; ATBP135; Atip1; B430010I23Rik; B430305I03Rik; C85752; Cctsg1-440; MD44; mKIAA1288; MTSG1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000112626
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InnateDB Gene
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IDBG-150350 (Mtus1)
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Protein Structure
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Function |
Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. {ECO:0000269PubMed:15123706, ECO:0000269PubMed:15539617, ECO:0000269PubMed:17068200}.
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Subcellular Localization |
Mitochondrion {ECO:0000250}. Golgi apparatus. Cell membrane. Nucleus. Note=In neurons, translocates into the nucleus after treatment with angiotensin-II.
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Disease Associations |
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Tissue Specificity |
Ubiquitously expressed, with highest levels in uterus and adrenal gland. {ECO:0000269PubMed:15539617}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2142572
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q5HZI1
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PhosphoSite |
PhosphoSite-Q5HZI1
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TrEMBL |
Q8K0Q3
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UniProt Splice Variant |
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Entrez Gene |
102103
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UniGene |
Mm.475369
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RefSeq |
NP_001273342
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MGI ID |
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MGI Symbol |
Mtus1
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OMIM |
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CCDS |
CCDS40328
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HPRD |
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IMGT |
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EMBL |
AC116511
AC156554
AF173380
AF493235
AK030510
AK031693
AK040710
AK129324
AK143781
AY246699
AY626781
AY626782
AY626783
BC030860
BC041777
BC042206
BC043321
BC089009
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GenPept |
AAD49746
AAH30860
AAH41777
AAH42206
AAH43321
AAH89009
AAO88908
AAQ06609
AAT45892
AAT45893
AAT45894
BAC26996
BAC27517
BAC30678
BAC98134
BAE25537
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