InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc7a2

Summary

InnateDB Protein

IDBP-401390.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc7a2

Protein Name

solute carrier family 7 (cationic amino acid transporter, y+ system), member 2

Synonyms

20.5; AI158848; Atrc2; CAT-2; Cat2; Tea;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000113729

InnateDB Gene

IDBG-150166 (Slc7a2)

Protein Structure

UniProt Annotation

Function

Low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine). Plays a regulatory role in classical or alternative activation of macrophages. {ECO:0000269PubMed:16670299, ECO:0000269PubMed:8385111}.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Highest expression in liver and T-cells. Also expressed in brain and lung. {ECO:0000269PubMed:16239143}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000064	L-ornithine transmembrane transporter activity
GO:0005289	high affinity arginine transmembrane transporter activity
GO:0015171	amino acid transmembrane transporter activity
GO:0015179	L-amino acid transmembrane transporter activity
GO:0015181	arginine transmembrane transporter activity
GO:0015189	L-lysine transmembrane transporter activity

Biological Process

GO:0002537	nitric oxide production involved in inflammatory response
GO:0003333	amino acid transmembrane transport
GO:0006809	nitric oxide biosynthetic process
GO:0006810	transport
GO:0006865	amino acid transport
GO:0015807	L-amino acid transport
GO:0015809	arginine transport
GO:0015819	lysine transport
GO:0015822	ornithine transport
GO:0042116	macrophage activation
GO:0043030	regulation of macrophage activation
GO:0050727	regulation of inflammatory response
GO:0055085	transmembrane transport
GO:1902475	L-alpha-amino acid transmembrane transport