Version 5.4
Mus musculus Gene: Slc7a2
Summary
InnateDB Gene IDBG-150166.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Slc7a2
Gene Name solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
Synonyms 20.5; AI158848; Atrc2; CAT-2; Cat2; Tea
Species Mus musculus
Ensembl Gene ENSMUSG00000031596
Encoded Proteins
IDBP-150168
solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
IDBP-150170
solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
IDBP-401392
solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
IDBP-401390
solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
IDBP-531839
solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000003989:
The protein encoded by this gene is a cationic amino acid transporter and a member of the APC (amino acid-polyamine-organocation) family of transporters. The encoded membrane protein is responsible for the cellular uptake of arginine, lysine and ornithine. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:40862396-40922308
Strand Forward strand
Band A4
Transcripts
ENSMUST00000098816 ENSMUSP00000096414
ENSMUST00000057784 ENSMUSP00000058866
ENSMUST00000118432 ENSMUSP00000112848
ENSMUST00000117077 ENSMUSP00000113729
ENSMUST00000141505 ENSMUSP00000114675
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000064 L-ornithine transmembrane transporter activity
GO:0005289 high affinity arginine transmembrane transporter activity
GO:0015171 amino acid transmembrane transporter activity
GO:0015179 L-amino acid transmembrane transporter activity
GO:0015181 arginine transmembrane transporter activity
GO:0015189 L-lysine transmembrane transporter activity
Biological Process
GO:0002537 nitric oxide production involved in inflammatory response
GO:0003333 amino acid transmembrane transport
GO:0006809 nitric oxide biosynthetic process
GO:0006810 transport
GO:0006865 amino acid transport
GO:0015807 L-amino acid transport
GO:0015809 arginine transport
GO:0015819 lysine transport
GO:0015822 ornithine transport
GO:0042116 macrophage activation
GO:0043030 regulation of macrophage activation
GO:0050727 regulation of inflammatory response
GO:0055085 transmembrane transport
GO:1902475 L-alpha-amino acid transmembrane transport
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000003989
View Gene Order
ENSBTAG00000010085
Not yet available
Pathways
NETPATH
REACTOME
REACT_247550
SLC-mediated transmembrane transport pathway
REACT_251788
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
REACT_253400
Transmembrane transport of small molecules pathway
REACT_230460
Amino acid transport across the plasma membrane pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.420895 Mm.454667
RefSeq NM_001044740 NM_007514 XM_006509250 XM_006509251 XM_006509252 XM_006509253
OMIM
CCDS CCDS22258 CCDS40327
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca