InnateDB Protein
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IDBP-401415.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Rab11fip3
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Protein Name
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RAB11 family interacting protein 3 (class II)
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000113048
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InnateDB Gene
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IDBG-154473 (Rab11fip3)
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Protein Structure
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Function |
Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. Also required for the structural integrity of the endosomal recycling compartment during interphase. {ECO:0000269PubMed:18685082}.
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Subcellular Localization |
Recycling endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cleavage furrow {ECO:0000250}. Midbody {ECO:0000250}. Note=In early mitosis remains diffuse and distributed through the cell. The onset of anaphase sequesters these vesicles to the centrosomes at the opposite poles of the cell. During telophase these vesicles move from the centrosomes, to the furrow, and then to the midbody to aid in abscission. Interaction with Rab11 mediates localization to endosomes. Interaction with ARF6 mediates localization to the midbody (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
10 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2444431
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InterPro |
IPR019018
Rab-binding domain FIP-RBD
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PFAM |
PF09457
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8CHD8
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PhosphoSite |
PhosphoSite-Q8CHD8
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
215445
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UniGene |
Mm.41191
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RefSeq |
NP_694780
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MGI ID |
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MGI Symbol |
Rab11fip3
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OMIM |
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CCDS |
CCDS50039
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HPRD |
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IMGT |
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EMBL |
AB093257
AC140047
AC159277
BC023364
BC037132
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GenPept |
AAH23364
AAH37132
BAC41441
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