InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rab11fip3

Summary

InnateDB Protein

IDBP-401418.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rab11fip3

Protein Name

RAB11 family interacting protein 3 (class II)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000112875

InnateDB Gene

IDBG-154473 (Rab11fip3)

Protein Structure

UniProt Annotation

Function

Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. Also required for the structural integrity of the endosomal recycling compartment during interphase. {ECO:0000269PubMed:18685082}.

Subcellular Localization

Recycling endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cleavage furrow {ECO:0000250}. Midbody {ECO:0000250}. Note=In early mitosis remains diffuse and distributed through the cell. The onset of anaphase sequesters these vesicles to the centrosomes at the opposite poles of the cell. During telophase these vesicles move from the centrosomes, to the furrow, and then to the midbody to aid in abscission. Interaction with Rab11 mediates localization to endosomes. Interaction with ARF6 mediates localization to the midbody (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0017137	Rab GTPase binding
GO:0030306	ADP-ribosylation factor binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0000910	cytokinesis
GO:0032456	endocytic recycling

Cellular Component

GO:0005634	nucleus
GO:0005768	endosome
GO:0005813	centrosome
GO:0016020	membrane
GO:0030496	midbody
GO:0032154	cleavage furrow
GO:0055037	recycling endosome
GO:0055038	recycling endosome membrane