InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cdon

Summary

InnateDB Protein

IDBP-401451.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cdon

Protein Name

cell adhesion molecule-related/down-regulated by oncogenes

Synonyms

Cd0; CDO; Orcam;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000113977

InnateDB Gene

IDBG-148540 (Cdon)

Protein Structure

UniProt Annotation

Function

Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells. Required for response to NTN3 and activation of NFATC3. {ECO:0000269PubMed:15520228, ECO:0000269PubMed:9786951}.

Subcellular Localization

Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in somites and the dorsal lips of the neural tube during embryogenesis. Detected at very low levels in adult tissues. {ECO:0000269PubMed:9786951}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0001708	cell fate specification
GO:0001934	positive regulation of protein phosphorylation
GO:0002088	lens development in camera-type eye
GO:0007224	smoothened signaling pathway
GO:0007520	myoblast fusion
GO:0009952	anterior/posterior pattern specification
GO:0010172	embryonic body morphogenesis
GO:0014816	satellite cell differentiation
GO:0016202	regulation of striated muscle tissue development
GO:0016337	single organismal cell-cell adhesion
GO:0021987	cerebral cortex development
GO:0043410	positive regulation of MAPK cascade
GO:0043497	regulation of protein heterodimerization activity
GO:0045663	positive regulation of myoblast differentiation
GO:0045664	regulation of neuron differentiation
GO:0045666	positive regulation of neuron differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048598	embryonic morphogenesis
GO:0048643	positive regulation of skeletal muscle tissue development
GO:0051057	positive regulation of small GTPase mediated signal transduction
GO:0051146	striated muscle cell differentiation
GO:0060059	embryonic retina morphogenesis in camera-type eye
GO:2000179	positive regulation of neural precursor cell proliferation

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0009986	cell surface

Protein Structure and Domains

PDB ID

MGI:1926387

InterPro

IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR003961 Fibronectin, type III
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin

PFAM

PF00041
PF01108
PF07679
PF07686
PF00047

PRINTS

PIRSF

SMART

SM00408
SM00409
SM00060

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q32MD9