InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fgfr1

Summary

InnateDB Protein

IDBP-401517.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fgfr1

Protein Name

fibroblast growth factor receptor 1

Synonyms

AW208770; bFGF-R-1; c-fgr; Eask; Fgfr-1; FLG; Flt-2; Hspy; MFR;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000113909

InnateDB Gene

IDBG-143767 (Fgfr1)

Protein Structure

UniProt Annotation

Function

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein. Nucleus. Cytoplasm, cytosol. Cytoplasmic vesicle. Note=After ligand binding, both receptor and ligand are rapidly internalized. Can translocate to the nucleus after internalization, or by translocation from the endoplasmic reticulum or Golgi apparatus to the cytosol, and from there to the nucleus.Isoform 1: Cell membrane; Single-pass type I membrane protein.Isoform 5: Cell membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:10821861}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	38 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005007	fibroblast growth factor-activated receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008201	heparin binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0017134	fibroblast growth factor binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001525	angiogenesis
GO:0001657	ureteric bud development
GO:0001701	in utero embryonic development
GO:0001759	organ induction
GO:0002053	positive regulation of mesenchymal cell proliferation
GO:0002062	chondrocyte differentiation
GO:0006468	protein phosphorylation
GO:0007420	brain development
GO:0007435	salivary gland morphogenesis
GO:0007605	sensory perception of sound
GO:0008284	positive regulation of cell proliferation
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0010468	regulation of gene expression
GO:0010629	negative regulation of gene expression
GO:0010863	positive regulation of phospholipase C activity
GO:0010976	positive regulation of neuron projection development
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0021769	orbitofrontal cortex development
GO:0021847	ventricular zone neuroblast division
GO:0030324	lung development
GO:0030326	embryonic limb morphogenesis
GO:0030901	midbrain development
GO:0035607	fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development
GO:0042127	regulation of cell proliferation
GO:0042472	inner ear morphogenesis
GO:0042473	outer ear morphogenesis
GO:0042474	middle ear morphogenesis
GO:0043406	positive regulation of MAP kinase activity
GO:0045666	positive regulation of neuron differentiation
GO:0045787	positive regulation of cell cycle
GO:0046777	protein autophosphorylation
GO:0048339	paraxial mesoderm development
GO:0048378	regulation of lateral mesodermal cell fate specification
GO:0048469	cell maturation
GO:0048514	blood vessel morphogenesis
GO:0048699	generation of neurons
GO:0048762	mesenchymal cell differentiation
GO:0060045	positive regulation of cardiac muscle cell proliferation
GO:0060117	auditory receptor cell development
GO:0060445	branching involved in salivary gland morphogenesis
GO:0060484	lung-associated mesenchyme development
GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
GO:0060979	vasculogenesis involved in coronary vascular morphogenesis
GO:0090080	positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
GO:2001239	regulation of extrinsic apoptotic signaling pathway in absence of ligand

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0043235	receptor complex

Protein Structure and Domains

PDB ID

MGI:95522

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR011009 Protein kinase-like domain
IPR013098 Immunoglobulin I-set
IPR013151 Immunoglobulin
IPR016248 Fibroblast growth factor receptor family
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF07679
PF00047

PRINTS

PR00109

PIRSF

PIRSF000628

SMART

SM00220
SM00408
SM00409
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References