Version 5.4
Mus musculus Gene: Fgfr1
Summary
InnateDB Gene IDBG-143767.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fgfr1
Gene Name fibroblast growth factor receptor 1
Synonyms AW208770; bFGF-R-1; c-fgr; Eask; Fgfr-1; FLG; Flt-2; Hspy; MFR
Species Mus musculus
Ensembl Gene ENSMUSG00000031565
Encoded Proteins
IDBP-143769
fibroblast growth factor receptor 1
IDBP-401517
fibroblast growth factor receptor 1
IDBP-401518
fibroblast growth factor receptor 1
IDBP-536075
fibroblast growth factor receptor 1
IDBP-534646
fibroblast growth factor receptor 1
IDBP-627142
fibroblast growth factor receptor 1
IDBP-716488
IDBP-717663
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000077782:
The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:25513654-25575714
Strand Forward strand
Band A2
Transcripts
ENSMUST00000084027 ENSMUSP00000081041
ENSMUST00000117179 ENSMUSP00000113909
ENSMUST00000119398 ENSMUSP00000113855
ENSMUST00000120106
ENSMUST00000155564 ENSMUSP00000117884
ENSMUST00000148322
ENSMUST00000124228 ENSMUSP00000116564
ENSMUST00000126118
ENSMUST00000138104
ENSMUST00000138455
ENSMUST00000145218
ENSMUST00000133936
ENSMUST00000167764 ENSMUSP00000131343
ENSMUST00000178276 ENSMUSP00000137515
ENSMUST00000179592 ENSMUSP00000136640
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 38 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005007 fibroblast growth factor-activated receptor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008201 heparin binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0017134 fibroblast growth factor binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001525 angiogenesis
GO:0001657 ureteric bud development
GO:0001701 in utero embryonic development
GO:0001759 organ induction
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0002062 chondrocyte differentiation
GO:0006468 protein phosphorylation
GO:0007420 brain development
GO:0007435 salivary gland morphogenesis
GO:0007605 sensory perception of sound
GO:0008284 positive regulation of cell proliferation
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0010468 regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010863 positive regulation of phospholipase C activity
GO:0010976 positive regulation of neuron projection development
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0021769 orbitofrontal cortex development
GO:0021847 ventricular zone neuroblast division
GO:0030324 lung development
GO:0030326 embryonic limb morphogenesis
GO:0030901 midbrain development
GO:0035607 fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development
GO:0042127 regulation of cell proliferation
GO:0042472 inner ear morphogenesis
GO:0042473 outer ear morphogenesis
GO:0042474 middle ear morphogenesis
GO:0043406 positive regulation of MAP kinase activity
GO:0043410 positive regulation of MAPK cascade
GO:0045666 positive regulation of neuron differentiation
GO:0045787 positive regulation of cell cycle
GO:0046777 protein autophosphorylation
GO:0048339 paraxial mesoderm development
GO:0048378 regulation of lateral mesodermal cell fate specification
GO:0048469 cell maturation
GO:0048514 blood vessel morphogenesis
GO:0048699 generation of neurons
GO:0048762 mesenchymal cell differentiation
GO:0060045 positive regulation of cardiac muscle cell proliferation
GO:0060117 auditory receptor cell development
GO:0060445 branching involved in salivary gland morphogenesis
GO:0060484 lung-associated mesenchyme development
GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
GO:0060979 vasculogenesis involved in coronary vascular morphogenesis
GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
GO:2001239 regulation of extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0043235 receptor complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000077782
View Gene Order
ENSBTAG00000015457
Not yet available
Pathways
NETPATH
REACTOME
REACT_222862
Klotho-mediated ligand binding pathway
REACT_239142
Innate Immune System pathway
REACT_188199
Signaling by the B Cell Receptor (BCR) pathway
REACT_188191
Signaling by ERBB2 pathway
REACT_205300
PI3K/AKT activation pathway
REACT_189085
Disease pathway
REACT_240250
Signaling by Insulin receptor pathway
REACT_188177
Signaling by FGFR in disease pathway
REACT_188579
Signaling by ERBB4 pathway
REACT_188578
Signaling by SCF-KIT pathway
REACT_202336
FGFR1c and Klotho ligand binding and activation pathway
REACT_226341
PIP3 activates AKT signaling pathway
REACT_230745
Immune System pathway
REACT_230639
Downstream signal transduction pathway
REACT_231729
Downstream signaling of activated FGFR pathway
REACT_198525
Negative regulation of FGFR signaling pathway
REACT_196588
Constitutive PI3K/AKT Signaling in Cancer pathway
REACT_203296
PI3K events in ERBB4 signaling pathway
REACT_223993
PI-3K cascade pathway
REACT_227330
FGFR ligand binding and activation pathway
REACT_242976
Signaling by EGFR pathway
REACT_259732
Insulin receptor signalling cascade pathway
REACT_188215
IRS-related events triggered by IGF1R pathway
REACT_188218
IGF1R signaling cascade pathway
REACT_188219
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_225874
FGFR1c ligand binding and activation pathway
REACT_213364
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_230708
Phospholipase C-mediated cascade pathway
REACT_240139
PI3K Cascade pathway
REACT_261444
Axon guidance pathway
REACT_196538
Signaling by activated point mutants of FGFR1 pathway
REACT_188204
Fc epsilon receptor (FCERI) signaling pathway
REACT_226735
PI3K/AKT Signaling in Cancer pathway
REACT_215461
Signal transduction by L1 pathway
REACT_196455
Signaling by FGFR mutants pathway
REACT_196452
Signaling by FGFR1 mutants pathway
REACT_219680
L1CAM interactions pathway
REACT_248921
Signalling by NGF pathway
REACT_229531
Adaptive Immune System pathway
REACT_263353
Signaling by PDGF pathway
REACT_234357
FRS2-mediated cascade pathway
REACT_188576
Developmental Biology pathway
REACT_94437
SHC-mediated cascade pathway
REACT_206286
GAB1 signalosome pathway
REACT_196511
Signaling by FGFR1 amplification mutants pathway
REACT_243154
IRS-related events pathway
REACT_237883
NGF signalling via TRKA from the plasma membrane pathway
REACT_242206
IRS-mediated signalling pathway
REACT_215348
PI3K events in ERBB2 signaling pathway
REACT_188257
Signal Transduction pathway
REACT_242456
Signaling by FGFR pathway
REACT_188180
Signaling by EGFR in Cancer pathway
REACT_237796
NCAM signaling for neurite out-growth pathway
REACT_216944
FGFR1 ligand binding and activation pathway
REACT_209507
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_188188
DAP12 interactions pathway
REACT_188185
DAP12 signaling pathway
KEGG
mmu05218
Melanoma pathway
mmu04810
Regulation of actin cytoskeleton pathway
mmu04010
MAPK signaling pathway pathway
mmu04520
Adherens junction pathway
mmu05215
Prostate cancer pathway
mmu05200
Pathways in cancer pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
FGF8 signaling (Mouse) pathway
INOH website
EPO signaling pathway pathway
INOH website
FGF signaling pathway pathway
INOH website
VEGF signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_121153
Signaling by activated point mutants of FGFR1 pathway
REACT_121398
Signaling by FGFR mutants pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_120999
Signaling by FGFR1 mutants pathway
REACT_116125
Disease pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04010
MAPK signaling pathway pathway
hsa05218
Melanoma pathway
hsa04520
Adherens junction pathway
hsa05215
Prostate cancer pathway
hsa05200
Pathways in cancer pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
FGF signaling pathway pathway
INOH website
VEGF signaling pathway pathway
PID NCI
glypican_1pathway
Glypican 1 network
fgf_pathway
FGF signaling pathway
syndecan_4_pathway
Syndecan-4-mediated signaling events
ncadherinpathway
N-cadherin signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.265716
RefSeq NM_001079908 NM_001079909 NM_010206 XM_006509010 XM_006509011 XM_006509012 XM_006509013 XM_006509014
OMIM
CCDS CCDS40304 CCDS52526 CCDS57614
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca