Version 5.4
Mus musculus Protein: Eme2
Summary
InnateDB Protein IDBP-401523.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Eme2
Protein Name essential meiotic endonuclease 1 homolog 2 (S. pombe)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000113936
InnateDB Gene IDBG-149747 (Eme2)
Protein Structure
UniProt Annotation
Function Interacts with MUS81 to form a DNA structure-specific endonuclease which cleaves substrates such as 3'-flap structures. {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0003677 DNA binding
GO:0004518 nuclease activity
GO:0004519 endonuclease activity
Biological Process
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0008150 biological_process
GO:0090305 nucleic acid phosphodiester bond hydrolysis
Cellular Component
GO:0005575 cellular_component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:1919889
InterPro IPR006166 ERCC4 domain
PFAM PF02732
PRINTS
PIRSF
SMART SM00891
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q56A04
PhosphoSite PhosphoSite-Q56A04
TrEMBL
UniProt Splice Variant
Entrez Gene 193838
UniGene Mm.440199
RefSeq NP_001156574
MGI ID
MGI Symbol Eme2
OMIM
CCDS CCDS50023
HPRD
IMGT
EMBL AC166102 BC092228
GenPept AAH92228

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca