Version 5.4
Mus musculus Gene: Eme2
Summary
InnateDB Gene IDBG-149747.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Eme2
Gene Name essential meiotic endonuclease 1 homolog 2 (S. pombe)
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000073436
Encoded Proteins
IDBP-401523
essential meiotic endonuclease 1 homolog 2 (S. pombe)
IDBP-401520
essential meiotic endonuclease 1 homolog 2 (S. pombe)
IDBP-535164
essential meiotic endonuclease 1 homolog 2 (S. pombe)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000197774:
EME2 forms a heterodimer with MUS81 (MIM 606591) that functions as an XPF (MIM 278760)-type flap/fork endonuclease in DNA repair (Ciccia et al., 2007 [PubMed 17289582]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:24888486-24895087
Strand Reverse strand
Band A3.3
Transcripts
ENSMUST00000121542 ENSMUSP00000113936
ENSMUST00000119848 ENSMUSP00000113167
ENSMUST00000139754 ENSMUSP00000118245
ENSMUST00000156659
ENSMUST00000145882
ENSMUST00000140688
ENSMUST00000127293
ENSMUST00000128953
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0003677 DNA binding
GO:0004518 nuclease activity
GO:0004519 endonuclease activity
Biological Process
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0008150 biological_process
GO:0090305 nucleic acid phosphodiester bond hydrolysis
Cellular Component
GO:0005575 cellular_component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000197774
View Gene Order
ENSBTAG00000016553
Not yet available
Cross-References
SwissProt Q56A04
TrEMBL D3Z6X0 D6RIK4
UniProt Splice Variant
Entrez Gene 193838
UniGene Mm.440199
RefSeq NM_001163102
OMIM
CCDS CCDS50023
HPRD
IMGT
MGI ID MGI:1919889
MGI Symbol Eme2
EMBL AC166102 BC092228
GenPept AAH92228
RNA Seq Atlas 193838

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca