InnateDB Protein
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IDBP-401549.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ank1
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Protein Name
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ankyrin 1, erythroid
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Synonyms
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Ank-1; nb; pale;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000112966
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InnateDB Gene
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IDBG-141556 (Ank1)
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Protein Structure
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Function |
Attaches integral membrane proteins to cytoskeletal elements; binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein; they retain most or all of these binding functions. In skeletal muscle, isoform Mu7 together with obscurin may provide a molecular link between the sarcoplasmic reticulum and myofibrils.
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Subcellular Localization |
Isoform Er1: Cytoplasm, cytoskeleton {ECO:0000250}. Note=Probably the other erythrocyte (Er) isoforms, are located near the surface of erythrocytic plasma membrane. {ECO:0000250}.Isoform Mu7: Membrane {ECO:0000250}.Isoform Mu8: Sarcoplasmic reticulum {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated |
Total |
9
[view]
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Protein-Protein |
9
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
15 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:88024
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q02357
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PhosphoSite |
PhosphoSite-Q02357
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
11733
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UniGene |
Mm.483054
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RefSeq |
XP_006509069
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MGI ID |
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MGI Symbol |
Ank1
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AK134267
AK147278
AK147597
AK158131
BC061219
M84756
U73972
U76758
X69063
X69064
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GenPept |
AAA37236
AAB37323
AAB37324
AAB37325
AAC24156
AAH61219
BAE22074
BAE27815
BAE28015
BAE34375
CAA48801
CAA48802
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