InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pex1

Summary

InnateDB Protein

IDBP-401599.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pex1

Protein Name

peroxisomal biogenesis factor 1

Synonyms

5430414H02Rik; E330005K07Rik; ZWS1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000113304

InnateDB Gene

IDBG-131610 (Pex1)

Protein Structure

UniProt Annotation

Function

Required for stability of PEX5 and protein import into the peroxisome matrix. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Peroxisome membrane {ECO:0000250}. Note=Associated with peroxisomal membranes. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005524	ATP binding
GO:0008022	protein C-terminus binding
GO:0008289	lipid binding
GO:0009378	four-way junction helicase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0032403	protein complex binding
GO:0042623	ATPase activity, coupled

Biological Process

GO:0006200	ATP catabolic process
GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0007031	peroxisome organization
GO:0016558	protein import into peroxisome matrix
GO:0060152	microtubule-based peroxisome localization

Cellular Component

GO:0005634	nucleus
GO:0005777	peroxisome
GO:0005778	peroxisomal membrane
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

MGI:1918632

InterPro

IPR003593 AAA+ ATPase domain
IPR003959 ATPase, AAA-type, core
IPR008824 DNA helicase, Holliday junction RuvB type, N-terminal
IPR009010 Aspartate decarboxylase-like domain
IPR015342 Peroxisome biogenesis factor 1, N-terminal
IPR015343 Peroxisome biogenesis factor 1, alpha/beta
IPR027417 P-loop containing nucleoside triphosphate hydrolase
IPR029067 CDC48 domain 2-like

PFAM

PF00004
PF07724
PF13304
PF05496
PF09262
PF09263

PRINTS

PIRSF

SMART

SM00382

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q5BL07