InnateDB Protein
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IDBP-401666.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Tbp
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Protein Name
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TATA box binding protein
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Synonyms
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Gtf2d; GTF2D1; SCA17; TFIID;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000112794
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InnateDB Gene
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IDBG-139921 (Tbp)
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Protein Structure
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Function |
General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre- initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1 with the rDNA promoter. SL1 is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus.
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Disease Associations |
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Tissue Specificity |
Ubiquitously expressed. {ECO:0000269PubMed:16412700}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
They are also associated with 146 interaction(s) predicted by orthology.
Experimentally validated |
Total |
54
[view]
|
Protein-Protein |
46
[view]
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Protein-DNA |
8
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
146 [view]
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Molecular Function |
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Biological Process |
GO:0006352
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DNA-templated transcription, initiation
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GO:0006366
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transcription from RNA polymerase II promoter
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GO:0006383
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transcription from RNA polymerase III promoter
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GO:0007283
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spermatogenesis
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GO:0045893
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positive regulation of transcription, DNA-templated
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Cellular Component |
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PDB ID |
MGI:101838
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InterPro |
IPR000814
TATA-box binding protein
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PFAM |
PF00352
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PRINTS |
PR00686
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P29037
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PhosphoSite |
PhosphoSite-P29037
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TrEMBL |
Q6RI65
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UniProt Splice Variant |
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Entrez Gene |
21374
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UniGene |
Mm.489273
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RefSeq |
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MGI ID |
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MGI Symbol |
Tbp
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OMIM |
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CCDS |
CCDS37454
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HPRD |
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IMGT |
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EMBL |
AC154378
AK085037
AY497019
BC012685
BC050136
CH466630
D01034
D86619
DQ906043
FJ770049
U63933
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GenPept |
AAB53097
AAH12685
AAH50136
AAR30866
ABL09363
ACN86312
BAA00840
BAA21084
BAC39346
EDL20459
EDL20461
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