Version 5.4
Mus musculus Protein: Litaf
Summary
InnateDB Protein IDBP-401671.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Litaf
Protein Name LPS-induced TN factor
Synonyms 3222402J11Rik; C85531; N4WBP3; TBX1;
Species Mus musculus
Ensembl Protein ENSMUSP00000112667
InnateDB Gene IDBG-132808 (Litaf)
Protein Structure
UniProt Annotation
Function Probable role in regulating transcription of specific genes. May regulate through NFKB1 the expression of the CCL2/MCP-1 chemokine. May play a role in tumor necrosis factor alpha (TNF- alpha) gene expression. {ECO:0000269PubMed:12355436, ECO:0000269PubMed:15025820}.
Subcellular Localization Lysosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Associated with membranes of lysosomes. {ECO:0000250}.
Disease Associations
Tissue Specificity Widely expressed. Highly expressed in liver. {ECO:0000269PubMed:12355436, ECO:0000269PubMed:15025820}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0050699 WW domain binding
Biological Process
GO:0001817 regulation of cytokine production
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0007568 aging
GO:0032496 response to lipopolysaccharide
GO:0042347 negative regulation of NF-kappaB import into nucleus
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0071222 cellular response to lipopolysaccharide
Cellular Component
GO:0005765 lysosomal membrane
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID MGI:1929512
InterPro IPR006629 LPS-induced tumor necrosis factor alpha factor
PFAM PF10601
PRINTS
PIRSF
SMART SM00714
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9JLJ0
PhosphoSite PhosphoSite-Q9JLJ0
TrEMBL E0CYR5
UniProt Splice Variant
Entrez Gene 56722
UniGene Mm.466843
RefSeq
MGI ID
MGI Symbol Litaf
OMIM
CCDS CCDS27958
HPRD
IMGT
EMBL AC164093 AF171100 AF220207 AF230522 AK018578 AK076162 AK151053 AK159533 BC018559
GenPept AAF27312 AAG44246 AAH18559 AAO49168 BAB31289 BAC36228 BAE30070 BAE35161

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca