InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pxdn

Summary

InnateDB Protein

IDBP-401717.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pxdn

Protein Name

peroxidasin homolog (Drosophila)

Synonyms

2310075M15Rik; C85409; E330004E07; mKIAA0230; VPO1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000113703

InnateDB Gene

IDBG-132328 (Pxdn)

Protein Structure

UniProt Annotation

Function

Displays low peroxidase activity and is likely to participate in H(2)O(2) metabolism and peroxidative reactions in the cardiovascular system (By similarity). Plays a role in extracellular matrix formation. {ECO:0000250}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000269PubMed:19590037}. Note=Enriched in the peritubular space of fibrotic kidneys.

Disease Associations

Tissue Specificity

Highly expressed in the cardiovascular system. {ECO:0000269PubMed:18929642}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004601	peroxidase activity
GO:0005201	extracellular matrix structural constituent
GO:0005515	protein binding
GO:0020037	heme binding
GO:0046872	metal ion binding

Biological Process

GO:0006979	response to oxidative stress
GO:0030198	extracellular matrix organization
GO:0042744	hydrogen peroxide catabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0005783	endoplasmic reticulum
GO:0031012	extracellular matrix

Protein Structure and Domains

PDB ID

MGI:1916925

InterPro

IPR000483 Cysteine-rich flanking region, C-terminal
IPR001007 von Willebrand factor, type C
IPR001611 Leucine-rich repeat
IPR002007 Haem peroxidase, animal
IPR003591 Leucine-rich repeat, typical subtype
IPR003596 Immunoglobulin V-set, subgroup
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR010255 Haem peroxidase
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin
IPR019791 Haem peroxidase, animal, subgroup

PFAM