Version 5.4
Mus musculus Gene: Pxdn
Summary
InnateDB Gene IDBG-132328.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pxdn
Gene Name peroxidasin homolog (Drosophila)
Synonyms 2310075M15Rik; C85409; E330004E07; mKIAA0230; VPO1
Species Mus musculus
Ensembl Gene ENSMUSG00000020674
Encoded Proteins
IDBP-401717
peroxidasin homolog (Drosophila)
IDBP-401716
peroxidasin homolog (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000130508:
Drosophila peroxidasin is an extracellular matrix-associated peroxidase (Horikoshi et al., 1999 [PubMed 10441517]). It is expressed exclusively in hemocytes derived from head mesoderm at a very early stage of differentiation. Peroxidasin exists as a homotrimer with a unique hybrid structure that combines an enzymatically functional peroxidase domain with motifs that are typically found in extracellular matrix-associated proteins. It is a secreted protein that contains a secretory recognition sequence at its N terminus. Peroxidasin catalyzes hydrogen peroxide-driven radioiodination, oxidations, and the formation of dityrosine in vitro. It is also thought to function in extracellular matrix consolidation, phagocytosis, and defense.[supplied by OMIM, Jul 2009]
This gene encodes a heme-containing peroxidase that is secreted into the extracellular matrix. It is involved in extracellular matrix formation, and may function in the physiological and pathological fibrogenic response in fibrotic kidney. Mutations in this gene cause corneal opacification and other ocular anomalies, and also microphthalmia and anterior segment dysgenesis. [provided by RefSeq, Aug 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:29938036-30017658
Strand Forward strand
Band A2
Transcripts
ENSMUST00000122328 ENSMUSP00000113703
ENSMUST00000118321 ENSMUSP00000113477
ENSMUST00000155318
ENSMUST00000155190
ENSMUST00000126233
ENSMUST00000137316
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004601 peroxidase activity
GO:0005201 extracellular matrix structural constituent
GO:0005515 protein binding
GO:0020037 heme binding
GO:0046872 metal ion binding
Biological Process
GO:0006979 response to oxidative stress
GO:0030198 extracellular matrix organization
GO:0042744 hydrogen peroxide catabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
GO:0005783 endoplasmic reticulum
GO:0031012 extracellular matrix
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000130508
View Gene Order
Cross-References
SwissProt
TrEMBL D3Z5M7
UniProt Splice Variant
Entrez Gene 69675
UniGene Mm.251774
RefSeq NM_181395 XM_006515205 XM_006515206
OMIM
CCDS CCDS25856
HPRD
IMGT
MGI ID MGI:1916925
MGI Symbol Pxdn
EMBL AC159626 AC165078
GenPept
RNA Seq Atlas 69675

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca