InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mthfd1l

Summary

InnateDB Protein

IDBP-401720.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mthfd1l

Protein Name

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000112897

InnateDB Gene

IDBG-131984 (Mthfd1l)

Protein Structure

UniProt Annotation

Function

May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2. {ECO:0000269PubMed:15611115}.

Subcellular Localization

Mitochondrion {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004329	formate-tetrahydrofolate ligase activity
GO:0004488	methylenetetrahydrofolate dehydrogenase (NADP+) activity
GO:0005524	ATP binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0006730	one-carbon metabolic process
GO:0009257	10-formyltetrahydrofolate biosynthetic process
GO:0009396	folic acid-containing compound biosynthetic process
GO:0015942	formate metabolic process
GO:0035999	tetrahydrofolate interconversion
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739

mitochondrion

Protein Structure and Domains

PDB ID

MGI:1924836

InterPro

IPR000559 Formate-tetrahydrofolate ligase, FTHFS
IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase
IPR020630 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
IPR020631 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF01268
PF00763
PF02882

PRINTS

PR00085

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q3V3R1