InnateDB Protein
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IDBP-401734.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Hmox2
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Protein Name
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heme oxygenase (decycling) 2
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Synonyms
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HO-2; HO2;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000113110
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InnateDB Gene
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IDBG-129962 (Hmox2)
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Protein Structure
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Function |
Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter.
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Subcellular Localization |
Microsome. Endoplasmic reticulum.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.
Experimentally validated |
Total |
12
[view]
|
Protein-Protein |
12
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
33 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:109373
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InterPro |
IPR002051
Haem oxygenase
IPR016053
Haem oxygenase-like
IPR016084
Haem oxygenase-like, multi-helical
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PFAM |
PF01126
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PRINTS |
PR00088
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PIRSF |
PIRSF000343
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O70252
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PhosphoSite |
PhosphoSite-O70252
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TrEMBL |
Q544R7
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UniProt Splice Variant |
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Entrez Gene |
15369
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UniGene |
Mm.272866
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RefSeq |
XP_006521866
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MGI ID |
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MGI Symbol |
Hmox2
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OMIM |
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CCDS |
CCDS27924
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HPRD |
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IMGT |
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EMBL |
AC166903
AF029874
AF054669
AF054670
AK032175
AK134536
AK141426
BC002011
CH466521
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GenPept |
AAC17981
AAC82363
AAC82364
AAH02011
BAC27744
BAE22174
BAE24682
EDK97247
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