Version 5.4
Mus musculus Gene: Hmox2
Summary
InnateDB Gene IDBG-129962.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hmox2
Gene Name heme oxygenase (decycling) 2
Synonyms HO-2; HO2
Species Mus musculus
Ensembl Gene ENSMUSG00000004070
Encoded Proteins
IDBP-129964
heme oxygenase (decycling) 2
IDBP-401735
heme oxygenase (decycling) 2
IDBP-401734
heme oxygenase (decycling) 2
IDBP-401733
heme oxygenase (decycling) 2
IDBP-543056
heme oxygenase (decycling) 2
IDBP-543057
heme oxygenase (decycling) 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000103415:
Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. Alternative splice variants encoding the same protein have been identified at this locus. [provided by RefSeq, Jul 2008]
Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family. Several alternatively spliced transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:4726361-4766742
Strand Forward strand
Band A1
Transcripts
ENSMUST00000004172 ENSMUSP00000004172
ENSMUST00000120232 ENSMUSP00000112397
ENSMUST00000118885 ENSMUSP00000113110
ENSMUST00000121529 ENSMUSP00000112378
ENSMUST00000154117 ENSMUSP00000122699
ENSMUST00000140367 ENSMUSP00000115932
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 33 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004392 heme oxygenase (decyclizing) activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0001666 response to hypoxia
GO:0006788 heme oxidation
GO:0006979 response to oxidative stress
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000103415
View Gene Order
ENSBTAG00000018937
Not yet available
Pathways
NETPATH
REACTOME
REACT_188937
Metabolism pathway
REACT_205755
Iron uptake and transport pathway
REACT_233393
Heme degradation pathway
REACT_253400
Transmembrane transport of small molecules pathway
REACT_233360
Metabolism of porphyrins pathway
KEGG
mmu00860
Porphyrin and chlorophyll metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_25060
Iron uptake and transport pathway
REACT_22297
Heme degradation pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_9431
Metabolism of porphyrins pathway
REACT_111217
Metabolism pathway
KEGG
hsa00860
Porphyrin and chlorophyll metabolism pathway
INOH
PID NCI
Cross-References
SwissProt O70252
TrEMBL D3YX62 D3YXN4 D3Z4A2 Q544R7
UniProt Splice Variant
Entrez Gene 15369
UniGene Mm.272866
RefSeq XM_006521803 NM_001136066 NM_010443 XM_006521804
OMIM
CCDS CCDS27924
HPRD
IMGT
MGI ID MGI:109373
MGI Symbol Hmox2
EMBL AC166903 AF029874 AF054669 AF054670 AK032175 AK134536 AK141426 BC002011 CH466521
GenPept AAC17981 AAC82363 AAC82364 AAH02011 BAC27744 BAE22174 BAE24682 EDK97247
RNA Seq Atlas 15369

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca