Version 5.4
Mus musculus Protein: Hmox2
Summary
InnateDB Protein IDBP-401735.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hmox2
Protein Name heme oxygenase (decycling) 2
Synonyms HO-2; HO2;
Species Mus musculus
Ensembl Protein ENSMUSP00000112397
InnateDB Gene IDBG-129962 (Hmox2)
Protein Structure
UniProt Annotation
Function Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter.
Subcellular Localization Microsome. Endoplasmic reticulum.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 33 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004392 heme oxygenase (decyclizing) activity
GO:0046872 metal ion binding
Biological Process
GO:0001666 response to hypoxia
GO:0006788 heme oxidation
GO:0006979 response to oxidative stress
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID MGI:109373
InterPro IPR002051 Haem oxygenase
IPR016053 Haem oxygenase-like
IPR016084 Haem oxygenase-like, multi-helical
PFAM PF01126
PRINTS PR00088
PIRSF PIRSF000343
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O70252
PhosphoSite PhosphoSite-O70252
TrEMBL Q544R7
UniProt Splice Variant
Entrez Gene 15369
UniGene Mm.272866
RefSeq NP_034573
MGI ID
MGI Symbol Hmox2
OMIM
CCDS CCDS27924
HPRD
IMGT
EMBL AC166903 AF029874 AF054669 AF054670 AK032175 AK134536 AK141426 BC002011 CH466521
GenPept AAC17981 AAC82363 AAC82364 AAH02011 BAC27744 BAE22174 BAE24682 EDK97247

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca