InnateDB Protein
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IDBP-401758.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Osbpl1a
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Protein Name
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oxysterol binding protein-like 1A
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Synonyms
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G430090F17Rik; Gm753; ORP-1; Osbpl1b;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000112895
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InnateDB Gene
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IDBG-129085 (Osbpl1a)
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Protein Structure
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Function |
Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3- phosphate. Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A (By similarity). {ECO:0000250}.
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Subcellular Localization |
Late endosome {ECO:0000250}. Note=Co- localizes with RAB7A, RAB9A and LAMP1 in late endosomes. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Ubiquitous. {ECO:0000269PubMed:12215260}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1927551
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InterPro |
IPR000648
Oxysterol-binding protein
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PFAM |
PF01237
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q91XL9
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PhosphoSite |
PhosphoSite-Q91XL9
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TrEMBL |
D3Z7I9
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UniProt Splice Variant |
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Entrez Gene |
64291
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UniGene |
Mm.490206
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RefSeq |
XP_006526211
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MGI ID |
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MGI Symbol |
Osbpl1a
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OMIM |
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CCDS |
CCDS57114
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HPRD |
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IMGT |
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EMBL |
AB017026
AC102055
AC131672
AF394063
AK168366
AY536214
BC076637
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GenPept |
AAH76637
AAK71661
AAT06024
BAA33012
BAE40301
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