InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cabyr

Summary

InnateDB Protein

IDBP-401764.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cabyr

Protein Name

calcium-binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2)

Synonyms

1700016C01Rik; 4933421A18Rik; CBP86; FSP-2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000113131

InnateDB Gene

IDBG-129056 (Cabyr)

Protein Structure

UniProt Annotation

Function

May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction. May bind calcium in vitro (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:12801634}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:12801634}. Cell projection, cilium, flagellum {ECO:0000269PubMed:12801634}. Note=Localizes to fibrous sheath including the surface of the longitudinal columns and ribs of the principal piece of sperm flagella.

Disease Associations

Tissue Specificity

Expressed in spermatozoa. {ECO:0000269PubMed:12801634}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0019904	protein domain specific binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001539	cilium or flagellum-dependent cell motility
GO:0019722	calcium-mediated signaling
GO:0048240	sperm capacitation
GO:0051259	protein oligomerization

Cellular Component

GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0031514	motile cilium
GO:0035686	sperm fibrous sheath
GO:0097228	sperm principal piece
GO:0097229	sperm end piece