InnateDB Protein
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IDBP-40197.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CDK5R1
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Protein Name
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cyclin-dependent kinase 5, regulatory subunit 1 (p35)
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Synonyms
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CDK5P35; CDK5R; NCK5A; p23; p25; p35; p35nck5a;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000318486
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InnateDB Gene
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IDBG-40195 (CDK5R1)
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Protein Structure
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Function |
p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution. {ECO:0000269PubMed:24235147}.
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Subcellular Localization |
Cyclin-dependent kinase 5 activator 1, p35: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=In the primary cortical neurons, p35 is present in the peripheries and nerve terminals.Cyclin-dependent kinase 5 activator 1, p25: Nucleus. Cytoplasm, perinuclear region. Note=The conversion of p35 to p25 relocalizes the protein from the cell periphery to the cytoplasm, in nuclear and perinuclear regions. In the primary cortical neurons, p25 is primarily concentrated in the cell soma and is largely absent from neurites.
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Disease Associations |
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Tissue Specificity |
Brain and neuron specific.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated |
Total |
37
[view]
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Protein-Protein |
36
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
6 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR004944
Cyclin-dependent kinase 5 activator
IPR013763
Cyclin-like
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PFAM |
PF03261
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PRINTS |
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PIRSF |
PIRSF009324
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SMART |
SM00385
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TIGRFAMs |
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Modification |
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SwissProt |
Q15078
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PhosphoSite |
PhosphoSite-Q15078
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
8851
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UniGene |
Hs.714132
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RefSeq |
NP_003876
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HUGO |
HGNC:1775
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OMIM |
603460
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CCDS |
CCDS11273
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HPRD |
04586
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IMGT |
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EMBL |
AY376350
BC020580
BT019573
CH471147
X80343
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GenPept |
AAH20580
AAQ74776
AAV38380
CAA56587
EAW80227
EAW80228
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