InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SIRPB1

Summary

InnateDB Protein

IDBP-40343.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SIRPB1

Protein Name

signal-regulatory protein beta 1

Synonyms

CD172b; SIRP-BETA-1;

Species

Homo sapiens

Ensembl Protein

ENSP00000371018

InnateDB Gene

IDBG-40341 (SIRPB1)

Protein Structure

UniProt Annotation

Function

Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Detected in monocytes and dendritic cells. {ECO:0000269PubMed:10604985}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007165	signal transduction
GO:0007166	cell surface receptor signaling pathway
GO:0045087	innate immune response

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR003597 Immunoglobulin C1-set
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin
IPR013162 CD80-like, immunoglobulin C2-set

PFAM

PF07654
PF07686
PF00047
PF08205

PRINTS

PIRSF

SMART

SM00407
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O00241