Version 5.4
| Homo sapiens Gene: SIRPB1 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-40341.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | SIRPB1 | ||||||||||||||||||
| Gene Name | signal-regulatory protein beta 1 | ||||||||||||||||||
| Synonyms | CD172b; SIRP-BETA-1 | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000101307 | ||||||||||||||||||
| Encoded Proteins |
signal-regulatory protein beta 1
signal-regulatory protein beta 1
signal-regulatory protein beta 1
signal-regulatory protein beta 1
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| Protein Structure | |||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 20:1563521-1620061 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | p13 | ||||||||||||||||||
| Transcripts | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
| No orthologs found for this gene | |||||||||||||||||||
| Pathways | |||||||||||||||||||
| NETPATH |
RANKL pathway
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| REACTOME |
DAP12 interactions pathway
Signal regulatory protein (SIRP) family interactions pathway
Cell-Cell communication pathway
Innate Immune System pathway
Immune System pathway
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| KEGG |
Osteoclast differentiation pathway
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| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | |||||||||||||||||||
| TrEMBL | H3BU43 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 10326 | ||||||||||||||||||
| UniGene | |||||||||||||||||||
| RefSeq | NM_001083910 NM_001135844 NM_006065 XM_005260641 XM_005260644 XM_006723535 | ||||||||||||||||||
| HUGO | HGNC:15928 | ||||||||||||||||||
| OMIM | 603889 | ||||||||||||||||||
| CCDS | CCDS13019 CCDS42850 CCDS46571 | ||||||||||||||||||
| HPRD | 04866 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AL049634 AL138804 AL592544 | ||||||||||||||||||
| GenPept | |||||||||||||||||||
| RNA Seq Atlas | 10326 | ||||||||||||||||||