InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SPACA3

Summary

InnateDB Protein

IDBP-40384.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SPACA3

Protein Name

sperm acrosome associated 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000269053

InnateDB Gene

IDBG-40382 (SPACA3)

Protein Structure

UniProt Annotation

Function

Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro. {ECO:0000269PubMed:12606493}.

Subcellular Localization

Isoform 1: Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. Note=Anterior acrosome in non- capacitated spermatozoa and retained in the equatorial segment and in the luminal face of both the inner and outer acrosomal membranes following capacitation and the acrosome reaction. {ECO:0000250}.Isoform 2: Secreted {ECO:0000305}.

Disease Associations

Tissue Specificity

The processed form is expressed in sperm (at protein level). Expressed in testis, epididymis and placenta. {ECO:0000269PubMed:12606493, ECO:0000269PubMed:16014814}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003796	lysozyme activity
GO:0005515	protein binding

Biological Process

GO:0009253	peptidoglycan catabolic process
GO:0009615	response to virus
GO:0016998	cell wall macromolecule catabolic process
GO:0035036	sperm-egg recognition
GO:0042117	monocyte activation
GO:0043032	positive regulation of macrophage activation
GO:0050766	positive regulation of phagocytosis
GO:0050830	defense response to Gram-positive bacterium

Cellular Component

GO:0001669	acrosomal vesicle
GO:0002080	acrosomal membrane
GO:0005576	extracellular region
GO:0005764	lysosome
GO:0016021	integral component of membrane
GO:0030141	secretory granule