InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ASIC2

Summary

InnateDB Protein

IDBP-40428.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ASIC2

Protein Name

amiloride-sensitive cation channel 1, neuronal

Synonyms

ACCN; ACCN1; ASIC2a; BNaC1; BNC1; hBNaC1; MDEG;

Species

Homo sapiens

Ensembl Protein

ENSP00000225823

InnateDB Gene

IDBG-40426 (ASIC2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005248	voltage-gated sodium channel activity
GO:0005261	cation channel activity
GO:0005272	sodium channel activity
GO:0005515	protein binding
GO:0015280	ligand-gated sodium channel activity
GO:0022839	ion gated channel activity

Biological Process

GO:0003026	regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback
GO:0006812	cation transport
GO:0006814	sodium ion transport
GO:0007268	synaptic transmission
GO:0007417	central nervous system development
GO:0007422	peripheral nervous system development
GO:0007602	phototransduction
GO:0007605	sensory perception of sound
GO:0009612	response to mechanical stimulus
GO:0010447	response to acidity
GO:0010468	regulation of gene expression
GO:0015672	monovalent inorganic cation transport
GO:0019229	regulation of vasoconstriction
GO:0030193	regulation of blood coagulation
GO:0034220	ion transmembrane transport
GO:0034765	regulation of ion transmembrane transport
GO:0035418	protein localization to synapse
GO:0035725	sodium ion transmembrane transport
GO:0042391	regulation of membrane potential
GO:0043066	negative regulation of apoptotic process
GO:0050915	sensory perception of sour taste
GO:0050974	detection of mechanical stimulus involved in sensory perception
GO:0051965	positive regulation of synapse assembly
GO:0055085	transmembrane transport
GO:0071229	cellular response to acid
GO:0071468	cellular response to acidity
GO:2001259	positive regulation of cation channel activity

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0043197	dendritic spine
GO:0045202	synapse