Version 5.4
Homo sapiens Gene: ASIC2
Summary
InnateDB Gene IDBG-40426.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ASIC2
Gene Name acid-sensing (proton-gated) ion channel 2
Synonyms ACCN; ACCN1; ASIC2a; BNaC1; BNC1; hBNaC1; MDEG
Species Homo sapiens
Ensembl Gene ENSG00000108684
Encoded Proteins
IDBP-40428
amiloride-sensitive cation channel 1, neuronal
IDBP-40430
amiloride-sensitive cation channel 1, neuronal
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene may play a role in neurotransmission. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 3 has been observed to co-assemble into proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct isoforms, have been identified. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:33013087-34174964
Strand Reverse strand
Band q12
Transcripts
ENST00000225823 ENSP00000225823
ENST00000359872 ENSP00000352934
ENST00000448983
ENST00000579816
ENST00000583395
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005248 voltage-gated sodium channel activity
GO:0005261 cation channel activity
GO:0005272 sodium channel activity
GO:0005515 protein binding
GO:0015280 ligand-gated sodium channel activity
GO:0022839 ion gated channel activity
Biological Process
GO:0003026 regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback
GO:0006812 cation transport
GO:0006814 sodium ion transport
GO:0007268 synaptic transmission
GO:0007417 central nervous system development
GO:0007422 peripheral nervous system development
GO:0007602 phototransduction
GO:0007605 sensory perception of sound
GO:0009612 response to mechanical stimulus
GO:0010447 response to acidity
GO:0010468 regulation of gene expression
GO:0015672 monovalent inorganic cation transport
GO:0019229 regulation of vasoconstriction
GO:0030193 regulation of blood coagulation
GO:0034220 ion transmembrane transport
GO:0034765 regulation of ion transmembrane transport
GO:0035418 protein localization to synapse
GO:0035725 sodium ion transmembrane transport
GO:0042391 regulation of membrane potential
GO:0043066 negative regulation of apoptotic process
GO:0050915 sensory perception of sour taste
GO:0050974 detection of mechanical stimulus involved in sensory perception
GO:0051965 positive regulation of synapse assembly
GO:0055085 transmembrane transport
GO:0071229 cellular response to acid
GO:0071468 cellular response to acidity
GO:2001259 positive regulation of cation channel activity
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043197 dendritic spine
GO:0045202 synapse
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020704
View Gene Order
ENSBTAG00000025200
Not yet available
Pathways
NETPATH
REACTOME
REACT_160189
Stimuli-sensing channels pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_25300
Ion channel transport pathway
KEGG
hsa04742
Taste transduction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.368417
RefSeq NM_001094 NM_183377
HUGO
OMIM
CCDS CCDS11276 CCDS42296
HPRD 03471
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca