InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ASIC2

Summary

InnateDB Protein

IDBP-40430.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ASIC2

Protein Name

amiloride-sensitive cation channel 1, neuronal

Synonyms

ACCN; ACCN1; ASIC2a; BNaC1; BNC1; hBNaC1; MDEG;

Species

Homo sapiens

Ensembl Protein

ENSP00000352934

InnateDB Gene

IDBG-40426 (ASIC2)

Protein Structure

UniProt Annotation

Function

Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate.

Subcellular Localization

Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Localized at the plasma membrane of neurons, in the soma and punctated peripheral processes. {ECO:0000250}.

Disease Associations

Tissue Specificity

Brain and spinal cord. Isoform 1 is also detected in testis, liver, colon and ovary. {ECO:0000269PubMed:10842183, ECO:0000269PubMed:8631835}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005272	sodium channel activity
GO:0005515	protein binding
GO:0015280	ligand-gated sodium channel activity

Biological Process

GO:0006814	sodium ion transport
GO:0007268	synaptic transmission
GO:0007417	central nervous system development
GO:0007422	peripheral nervous system development
GO:0010468	regulation of gene expression
GO:0015672	monovalent inorganic cation transport
GO:0030193	regulation of blood coagulation
GO:0034220	ion transmembrane transport
GO:0035725	sodium ion transmembrane transport
GO:0050915	sensory perception of sour taste
GO:0055085	transmembrane transport