Version 5.4
Homo sapiens Protein: IL17RB
Summary
InnateDB Protein IDBP-40445.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL17RB
Protein Name interleukin 17 receptor B
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000288167
InnateDB Gene IDBG-40441 (IL17RB)
Protein Structure
UniProt Annotation
Function Receptor for the proinflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells. {ECO:0000269PubMed:11058597}.
Subcellular Localization Isoform 1: Cell membrane; Single-pass type I membrane protein.Isoform 2: Secreted.
Disease Associations
Tissue Specificity Expressed in several endocrine tissues, mostly in fetal and adult liver, kidney, pancreas, testis, colon, brain and small intestine; not detected in peripheral blood leukocytes, lymphoid organs, and most cell lines.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004896 cytokine receptor activity
Biological Process
GO:0001558 regulation of cell growth
GO:0006952 defense response
GO:0019221 cytokine-mediated signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR013568 SEFIR
PFAM PF08357
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NRM6
PhosphoSite PhosphoSite-Q9NRM6
TrEMBL
UniProt Splice Variant
Entrez Gene 55540
UniGene Hs.654970
RefSeq NP_061195
HUGO HGNC:18015
OMIM 605458
CCDS CCDS2874
HPRD 05677
IMGT
EMBL AF208110 AF208111 AF212365 AF250309 AY359122 AY518533 BC000980
GenPept AAF78776 AAF86051 AAF86052 AAH00980 AAK37428 AAQ89956 AAR89910

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca