Version 5.4
Homo sapiens Protein: SLC39A5
Summary
InnateDB Protein IDBP-40456.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC39A5
Protein Name solute carrier family 39 (metal ion transporter), member 5
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000266980
InnateDB Gene IDBG-40452 (SLC39A5)
Protein Structure
UniProt Annotation
Function May play a role in polarized cells by carrying out serosal-to-mucosal zinc transport. Seems to play a central role in controlling organismal zinc status (By similarity). {ECO:0000250}.
Subcellular Localization Basolateral cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in liver, kidney, pancreas, small intestine, colon, spleen, fetal liver and fetal kidney. {ECO:0000269PubMed:15322118}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0046873 metal ion transmembrane transporter activity
Biological Process
GO:0006829 zinc ion transport
GO:0030001 metal ion transport
GO:0034224 cellular response to zinc ion starvation
GO:0055085 transmembrane transport
GO:0061351 neural precursor cell proliferation
GO:0070315 G1 to G0 transition involved in cell differentiation
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR003689 Zinc/iron permease
PFAM PF02535
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6ZMH5
PhosphoSite PhosphoSite-Q6ZMH5
TrEMBL C9JVC6
UniProt Splice Variant
Entrez Gene 283375
UniGene Hs.591018
RefSeq NP_001128667
HUGO HGNC:20502
OMIM 608730
CCDS CCDS8912
HPRD
IMGT
EMBL AC073896 AK172768 AK313188 BC027884 CH471054
GenPept AAH27884 BAD18751 BAG36005 EAW96916 EAW96917 EAW96918

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca