InnateDB Protein
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IDBP-40459.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ASMT
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Protein Name
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acetylserotonin O-methyltransferase
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Synonyms
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ASMTY; HIOMT; HIOMTY;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000370639
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InnateDB Gene
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IDBG-40457 (ASMT)
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Protein Structure
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Function |
Isoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5- methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity. {ECO:0000269PubMed:22775292}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
Expressed in the pineal gland (at protein level). In the retina, very low expression is found at the mRNA level (PubMed:7989373), and not at the protein level (PubMed:8574683). {ECO:0000269PubMed:22775292, ECO:0000269PubMed:7989373, ECO:0000269PubMed:8574683}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
Accession |
GO Term |
GO:0008168
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methyltransferase activity
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GO:0008171
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O-methyltransferase activity
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GO:0008757
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S-adenosylmethionine-dependent methyltransferase activity
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GO:0017096
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acetylserotonin O-methyltransferase activity
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GO:0042802
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identical protein binding
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GO:0042803
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protein homodimerization activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001077
O-methyltransferase, family 2
IPR016461
Caffeate O-methyltransferase (COMT) family
IPR029063
S-adenosyl-L-methionine-dependent methyltransferase-like
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PFAM |
PF00891
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PRINTS |
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PIRSF |
PIRSF005739
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P46597
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PhosphoSite |
PhosphoSite-
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TrEMBL |
A0A024RBT9
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UniProt Splice Variant |
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Entrez Gene |
438
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UniGene |
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RefSeq |
NP_004034
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HUGO |
HGNC:750
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OMIM |
402500
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CCDS |
CCDS14117
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HPRD |
02058
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IMGT |
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EMBL |
AK314922
AL683807
BC001620
CH471074
M83779
U11089
U11090
U11091
U11092
U11093
U11094
U11095
U11096
U11097
U11098
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GenPept |
AAA17020
AAA58582
AAA58583
AAA75289
AAA75290
AAA75291
AAH01620
BAG37430
EAW98685
EAW98686
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