InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ASMT

Summary

InnateDB Protein

IDBP-40459.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ASMT

Protein Name

acetylserotonin O-methyltransferase

Synonyms

ASMTY; HIOMT; HIOMTY;

Species

Homo sapiens

Ensembl Protein

ENSP00000370639

InnateDB Gene

IDBG-40457 (ASMT)

Protein Structure

UniProt Annotation

Function

Isoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5- methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity. {ECO:0000269PubMed:22775292}.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed in the pineal gland (at protein level). In the retina, very low expression is found at the mRNA level (PubMed:7989373), and not at the protein level (PubMed:8574683). {ECO:0000269PubMed:22775292, ECO:0000269PubMed:7989373, ECO:0000269PubMed:8574683}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008168	methyltransferase activity
GO:0008171	O-methyltransferase activity
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity
GO:0017096	acetylserotonin O-methyltransferase activity
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0006412	translation
GO:0030187	melatonin biosynthetic process
GO:0032259	methylation
GO:0034641	cellular nitrogen compound metabolic process
GO:0044281	small molecule metabolic process
GO:0046219	indolalkylamine biosynthetic process
GO:2000019	negative regulation of male gonad development

Cellular Component

GO:0005829

cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR001077 O-methyltransferase, family 2
IPR016461 Caffeate O-methyltransferase (COMT) family
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like

PFAM

PF00891

PRINTS

PIRSF

PIRSF005739

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P46597