Version 5.4
Homo sapiens Gene: ASMT
Summary
InnateDB Gene IDBG-40457.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ASMT
Gene Name acetylserotonin O-methyltransferase
Synonyms ASMTY; HIOMT; HIOMTY
Species Homo sapiens
Ensembl Gene ENSG00000196433
Encoded Proteins
IDBP-40459
acetylserotonin O-methyltransferase
IDBP-40461
acetylserotonin O-methyltransferase
IDBP-40463
acetylserotonin O-methyltransferase
IDBP-361114
acetylserotonin O-methyltransferase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene belongs to the methyltransferase superfamily, and is located in the pseudoautosomal region (PAR) at the end of the short arms of the X and Y chromosomes. The encoded enzyme catalyzes the final reaction in the synthesis of melatonin, and is abundant in the pineal gland. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome X:1615001-1643081
Strand Forward strand
Band p22.33
Transcripts
ENST00000381241 ENSP00000370639
ENST00000381233 ENSP00000370631
ENST00000381229 ENSP00000370627
ENST00000432523 ENSP00000392053
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0008168 methyltransferase activity
GO:0008171 O-methyltransferase activity
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity
GO:0017096 acetylserotonin O-methyltransferase activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006412 translation
GO:0030187 melatonin biosynthetic process
GO:0032259 methylation
GO:0034641 cellular nitrogen compound metabolic process
GO:0044281 small molecule metabolic process
GO:0046219 indolalkylamine biosynthetic process
GO:2000019 negative regulation of male gonad development
Cellular Component
GO:0005829 cytosol
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_15439
Serotonin and melatonin biosynthesis pathway
REACT_15513
Amine-derived hormones pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_111217
Metabolism pathway
KEGG
hsa00380
Tryptophan metabolism pathway
INOH
INOH website
Tryptophan degradation pathway
PID NCI
Cross-References
SwissProt P46597
TrEMBL A0A024RBT9 I7HFW6 X5D2A4 X5D784
UniProt Splice Variant
Entrez Gene 438
UniGene
RefSeq NM_001171038 NM_001171039 NM_004043
HUGO HGNC:750
OMIM 300015 402500
CCDS CCDS14117 CCDS55364
HPRD
IMGT
EMBL AK314922 AL683807 BC001620 CH471074 KJ534774 KJ534775 KJ534776 M83779 U11089 U11090 U11091 U11092 U11093 U11094 U11095 U11096 U11097 U11098
GenPept AAA17020 AAA58582 AAA58583 AAA75289 AAA75290 AAA75291 AAH01620 AHW56414 AHW56415 AHW56416 BAG37430 EAW98685 EAW98686
RNA Seq Atlas 438

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca