Homo sapiens Protein: ASMT | |||||||||||||
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Summary | |||||||||||||
InnateDB Protein | IDBP-40463.7 | ||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||
Gene Symbol | ASMT | ||||||||||||
Protein Name | acetylserotonin O-methyltransferase | ||||||||||||
Synonyms | ASMTY; HIOMT; HIOMTY; | ||||||||||||
Species | Homo sapiens | ||||||||||||
Ensembl Protein | ENSP00000370627 | ||||||||||||
InnateDB Gene | IDBG-40457 (ASMT) | ||||||||||||
Protein Structure | |||||||||||||
UniProt Annotation | |||||||||||||
Function | Isoform 1 catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5- methoxytryptamine). Isoform 2 and isoform 3 lack enzyme activity. {ECO:0000269PubMed:22775292}. | ||||||||||||
Subcellular Localization | |||||||||||||
Disease Associations | |||||||||||||
Tissue Specificity | Expressed in the pineal gland (at protein level). In the retina, very low expression is found at the mRNA level (PubMed:7989373), and not at the protein level (PubMed:8574683). {ECO:0000269PubMed:22775292, ECO:0000269PubMed:7989373, ECO:0000269PubMed:8574683}. | ||||||||||||
Comments | |||||||||||||
Interactions | |||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||
PDB ID | |||||||||||||
InterPro |
IPR001077
O-methyltransferase, family 2 IPR013217 Methyltransferase type 12 IPR016461 Caffeate O-methyltransferase (COMT) family IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like |
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PFAM |
PF00891
PF08242 |
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PRINTS | |||||||||||||
PIRSF |
PIRSF005739
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SMART | |||||||||||||
TIGRFAMs | |||||||||||||
Post-translational Modifications | |||||||||||||
Modification | |||||||||||||
Cross-References | |||||||||||||
SwissProt | P46597 | ||||||||||||
PhosphoSite | PhosphoSite- | ||||||||||||
TrEMBL | X5D2A4 | ||||||||||||
UniProt Splice Variant | |||||||||||||
Entrez Gene | 438 | ||||||||||||
UniGene | |||||||||||||
RefSeq | |||||||||||||
HUGO | HGNC:750 | ||||||||||||
OMIM | 402500 | ||||||||||||
CCDS | |||||||||||||
HPRD | 02058 | ||||||||||||
IMGT | |||||||||||||
EMBL | AK314922 AL683807 BC001620 KJ534774 KJ534776 M83779 U11089 U11090 U11091 U11092 U11093 U11094 U11095 U11096 U11097 U11098 | ||||||||||||
GenPept | AAA17020 AAA58582 AAA58583 AAA75289 AAA75290 AAA75291 AAH01620 AHW56414 AHW56416 BAG37430 | ||||||||||||